{"id":"betanaphthol","rwe":[{"pmid":"41340703","year":"2025","title":"Interrogating the Azo-Hydrazo Proton Transfer Process in the Excited State Using a Multipronged Spectroscopic Study: Effect of Annulation and Solvent.","finding":"","journal":"ACS physical chemistry Au","studyType":"Clinical Study"},{"pmid":"41306878","year":"2025","title":"Magnetic lignin-supported sulfonic acid ionic liquid: a novel catalyst for synthesis of 2-amino-4-aryl-4H-benzo[f]chromen-3-carbonitrile derivatives.","finding":"","journal":"RSC advances","studyType":"Clinical Study"},{"pmid":"41099973","year":"2026","title":"Nanozyme-Facilitated In-Situ Fluorogenic Ratiometric Nanosensor for Ultrasensitive and Selective Dopamine Detection.","finding":"","journal":"Journal of fluorescence","studyType":"Clinical Study"},{"pmid":"40942547","year":"2025","title":"Efficient Electrolytic Refining of Crude Solder Assisted by Additives in a Fluosilicic Acid System.","finding":"","journal":"Materials (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"40675283","year":"2025","title":"Pectin-based magnetic molecularly imprinted polymer cross-linked via the Betti reaction and decorated by silver NPs (Fe(3)O(4)@MIP/Ag): A safe and potential antibacterial nano-carrier for highly sustained release of tetracycline.","finding":"","journal":"International journal of biological macromolecules","studyType":"Clinical Study"}],"tags":[{"label":"betanaphthol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":["NCT07325253","NCT05727163","NCT02442440"],"aliases":[],"patents":[],"pricing":[],"allNames":"2-naphthol","offLabel":[],"synonyms":["2-naphthol","2-Hydroxynaphthalene","betanaphthol","2-Naphthalenol"],"timeline":[],"brandName":"2-Naphthol","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"betanaphthol","explanation":"Imagine 2-Naphthol as a key that fits into a specific lock on a cell. When it binds to this lock, it can trigger a series of events that ultimately lead to a therapeutic effect. However, the exact nature of this lock and the events that follow are still not well understood.","oneSentence":"2-Naphthol is thought to exert its effects through a mechanism that involves binding to specific cellular targets, although the exact details of this process are not well understood.","technicalDetail":"The precise mechanism of action of 2-Naphthol is unclear, but it is believed to involve interaction with cellular proteins or receptors, potentially influencing signaling pathways or modulating gene expression."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/2-Naphthol","title":"2-Naphthol","extract":"2-Naphthol, or β-naphthol, is a fluorescent colorless (or occasionally yellow) crystalline solid with the formula C10H7OH. It is an isomer of 1-naphthol, differing by the location of the hydroxyl group on the naphthalene ring. The naphthols are naphthalene homologues of phenol, but more reactive. Both isomers are soluble in simple alcohols, ethers, and chloroform. 2-Naphthol is a widely used intermediate for the production of dyes and other compounds."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3370","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=betanaphthol","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/2-Naphthol","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T09:02:43.415559","biosimilars":[],"competitors":[],"dataSources":[{"url":"https://clinicaltrials.gov","name":"ClinicalTrials.gov","fields":["trialDetails","trials"],"retrievedDate":"2026-04-07"},{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"betanaphthol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT07325253","phase":"Phase 2","title":"A Pilot Study to Correlate 4-18F- Fluoro-1-naphthol 18F-4FN PET/CT Imaging With Chronic Graft Versus Host Disease Manifestations","status":"RECRUITING","sponsor":"M.D. Anderson Cancer Center","isPivotal":false,"enrollment":16,"indication":"Pilot Study, PET/CT Imaging","completionDate":"2030-01-03"},{"nctId":"NCT05727163","phase":"Phase 2","title":"FOLFOX Via Hepatic Artery Infusion Chemotherapy (HAI) Plus Systemic Irinotecan With or Without Bevacizumab Versus Systemic FOLFOXIRI With or Without Bevacizumab in Patients With Initially Unresectable","status":"RECRUITING","sponsor":"Sun Yat-sen University","isPivotal":false,"enrollment":194,"indication":"Colorectal Cancer Metastatic","completionDate":"2026-12-31"},{"nctId":"NCT02442440","phase":"Phase 1","title":"Effectiveness of Anisodamine for the Treatment of Critically Ill Patients With Septic Shock: a Randomized Controlled Trial","status":"COMPLETED","sponsor":"Jinhua Central Hospital","isPivotal":false,"enrollment":355,"indication":"Septic Shock","completionDate":"2020-10-01"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"MMSL":"NOCODE","NDDF":"003831","UNII":"P2Z71CIK5H","CHEBI":"CHEBI:10432","UMLSCUI":"C0046413","ChEMBL_ID":"CHEMBL14126","PDB_CHEM_ID":"03V","PUBCHEM_CID":"8663","MESH_SUPPLEMENTAL_RECORD_UI":"C028405"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":249,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2025 Nov 26","pmid":"41340703","title":"Interrogating the Azo-Hydrazo Proton Transfer Process in the Excited State Using a Multipronged Spectroscopic Study: Effect of Annulation and Solvent.","journal":"ACS physical chemistry Au"},{"date":"2025 Nov 24","pmid":"41306878","title":"Magnetic lignin-supported sulfonic acid ionic liquid: a novel catalyst for synthesis of 2-amino-4-aryl-4H-benzo[f]chromen-3-carbonitrile derivatives.","journal":"RSC advances"},{"date":"2026 Jan","pmid":"41099973","title":"Nanozyme-Facilitated In-Situ Fluorogenic Ratiometric Nanosensor for Ultrasensitive and Selective Dopamine Detection.","journal":"Journal of fluorescence"},{"date":"2025 Sep 2","pmid":"40942547","title":"Efficient Electrolytic Refining of Crude Solder Assisted by Additives in a Fluosilicic Acid System.","journal":"Materials (Basel, Switzerland)"},{"date":"2025 Aug","pmid":"40675283","title":"Pectin-based magnetic molecularly imprinted polymer cross-linked via the Betti reaction and decorated by silver NPs (Fe(3)O(4)@MIP/Ag): A safe and potential antibacterial nano-carrier for highly sustained release of tetracycline.","journal":"International journal of biological macromolecules"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"2-Naphthol is a small molecule with the synonyms 2-NAPHTHOL, BETANAPHTOL, and NSC-2044. It is being studied in clinical trials for various conditions, including colorectal cancer metastatic, septic shock, and host disease manifestation, among others.","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}