{"id":"betamethasone-gentamicin-tolnaftato-cleoquinol","safety":{"commonSideEffects":[{"rate":"null","effect":"hypersensitivity reactions"},{"rate":"null","effect":"nausea"},{"rate":"null","effect":"vomiting"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Betamethasone works by binding to glucocorticoid receptors, which reduces the production of pro-inflammatory cytokines. Gentamicin works by binding to bacterial ribosomes, inhibiting protein synthesis and ultimately killing bacteria. Tolnaftate works by inhibiting the enzyme squalene epoxidase, which is necessary for fungal cell wall synthesis. Cleocinol works by binding to the bacterial cell wall, inhibiting cell wall synthesis and ultimately killing bacteria.","oneSentence":"Betamethasone is a corticosteroid that reduces inflammation, gentamicin is an antibiotic that kills bacteria, tolnaftate is an antifungal that inhibits fungal growth, and cleocinol is an antibiotic that inhibits bacterial cell wall synthesis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:04:07.076Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"skin infections"},{"name":"wound infections"}]},"trialDetails":[{"nctId":"NCT01429701","phase":"PHASE3","title":"Effectiveness of Polymyxin B Sulphate + Prednisolone + Benzocaine + Clioquinol in Acute and Sub-acute Dermatitis Eczematous","status":"COMPLETED","sponsor":"EMS","startDate":"2012-05","conditions":"Eczema","enrollment":76}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"betamethasone + gentamicin + tolnaftato + cleoquinol","genericName":"betamethasone + gentamicin + tolnaftato + cleoquinol","companyName":"EMS","companyId":"ems","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Betamethasone is a corticosteroid that reduces inflammation, gentamicin is an antibiotic that kills bacteria, tolnaftate is an antifungal that inhibits fungal growth, and cleocinol is an antibiotic that inhibits bacterial cell wall synthesis. Used for skin infections, wound infections.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}