{"id":"betamethasone-butyrate-propionate","rwe":[{"pmid":"41137524","year":"2026","title":"Combined Maxacalcitol/Betamethasone Butyrate Propionate Ointment Possesses Long-Term Sustained Effects of Inducing Regulatory T Cells and Downregulating the Th17 Response, Even After Discontinuation of Its Application in Imiquimod-Induced Psoriasiform Dermatitis.","finding":"","journal":"The Journal of dermatology","studyType":"Clinical Study"},{"pmid":"39310604","year":"2024","title":"Resolution of Molluscum Contagiosum After Discontinuation of Topical Corticosteroids During Dupilumab Therapy for Atopic Dermatitis: A Case Report.","finding":"","journal":"Cureus","studyType":"Clinical Study"},{"pmid":"38496201","year":"2024","title":"Purpuric Type Drug Eruption Caused by Azithromycin: A Case Report and Literature Review.","finding":"","journal":"Cureus","studyType":"Clinical Study"},{"pmid":"36464312","year":"2022","title":"[A Case of Contact Dermatitis Due to Ultrasonography Gel].","finding":"","journal":"Journal of UOEH","studyType":"Clinical Study"},{"pmid":"33938439","year":"2021","title":"Lichen Planus Pigmentosus Associated with Topical Olive Oil Application.","finding":"","journal":"Skinmed","studyType":"Clinical Study"}],"tags":[{"label":"Corticosteroid","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Anti-Asthmatic Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Glucocorticoids","category":"pharmacology"},{"label":"Hormones","category":"pharmacology"},{"label":"Respiratory System Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"_fixedAt":"2026-03-30T16:36:54.694677","allNames":"antebate","offLabel":[],"synonyms":["antebate","betamethasone butyrate propionate"],"timeline":[],"brandName":"Antebate","ecosystem":[],"mechanism":{"moaClass":"Corticosteroid Hormone Receptor Agonists","modality":"Small Molecule","drugClass":"Corticosteroid","explanation":"Imagine your body's immune response is like a fire alarm that goes off when it senses something wrong. Antebate helps turn off the alarm by reducing the production of chemical signals that trigger the alarm. This helps to reduce inflammation and calm down the immune response.","oneSentence":"Antebate works by inhibiting the production of inflammatory mediators.","technicalDetail":"Antebate exerts its anti-inflammatory effects by inhibiting the transcription of inflammatory genes, primarily through the suppression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and other transcription factors."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/352","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=betamethasone%20butyrate%20propionate","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=betamethasone butyrate propionate","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:58:31.257882","biosimilars":[],"competitors":[],"genericName":"betamethasone butyrate propionate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"_fixedFields":["pubmed(19)"],"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT04220554","phase":"NA","title":"Improvement of Psoriasis Patients' Adherence to Topical Drugs","status":"COMPLETED","sponsor":"Odense University Hospital","startDate":"2020-06-19","conditions":["Psoriasis Vulgaris"],"enrollment":103,"completionDate":"2022-06-01"},{"nctId":"NCT03758365","phase":"PHASE1","title":"Evaluation of the Vasoconstriction Properties of MC2-01 Cream","status":"COMPLETED","sponsor":"MC2 Therapeutics","startDate":"2018-11-05","conditions":["Vasoconstriction"],"enrollment":36,"completionDate":"2018-11-23"},{"nctId":"NCT02973776","phase":"PHASE1","title":"Vasoconstriction Trial With LEO 90100 Aerosol Foam","status":"COMPLETED","sponsor":"LEO Pharma","startDate":"2016-12","conditions":["Psoriasis Vulgaris"],"enrollment":36,"completionDate":"2017-02"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"MMSL":"10006","NDDF":"002168","UNII":"50FH5AG9RW","CHEBI":"CHEBI:135815","VANDF":"4018644","INN_ID":"1045","RXNORM":"1514","UMLSCUI":"C2698381","ChEMBL_ID":"CHEMBL1697785","KEGG_DRUG":"D02032","DRUGBANK_ID":"DB00443","PUBCHEM_CID":"71470","SNOMEDCT_US":"116571008","MESH_DESCRIPTOR_UI":"D001623","MESH_SUPPLEMENTAL_RECORD_UI":"C000612965"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":19,"therapeuticAreas":["Immunology"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Jan","pmid":"41137524","title":"Combined Maxacalcitol/Betamethasone Butyrate Propionate Ointment Possesses Long-Term Sustained Effects of Inducing Regulatory T Cells and Downregulating the Th17 Response, Even After Discontinuation of Its Application in Imiquimod-Induced Psoriasiform Dermatitis.","journal":"The Journal of dermatology"},{"date":"2024 Aug","pmid":"39310604","title":"Resolution of Molluscum Contagiosum After Discontinuation of Topical Corticosteroids During Dupilumab Therapy for Atopic Dermatitis: A Case Report.","journal":"Cureus"},{"date":"2024 Feb","pmid":"38496201","title":"Purpuric Type Drug Eruption Caused by Azithromycin: A Case Report and Literature Review.","journal":"Cureus"},{"date":"2022","pmid":"36464312","title":"[A Case of Contact Dermatitis Due to Ultrasonography Gel].","journal":"Journal of UOEH"},{"date":"2021","pmid":"33938439","title":"Lichen Planus Pigmentosus Associated with Topical Olive Oil Application.","journal":"Skinmed"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Antebate, also known as betamethasone butyrate propionate, is a corticosteroid medication. It is a small molecule that works by inhibiting the production of inflammatory mediators, thereby reducing inflammation and immune responses. Antebate is used to treat various skin conditions, but its specific indications are not well-documented. The commercial status of Antebate is unclear, and it may be patented or have generic manufacturers. As a corticosteroid, Antebate carries key safety considerations, including potential skin atrophy and systemic effects.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}