{"id":"betadine-ophthalmic-prep-solution","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation"},{"rate":null,"effect":"Conjunctival hyperemia"},{"rate":null,"effect":"Transient stinging or discomfort"},{"rate":null,"effect":"Allergic reaction (iodine sensitivity)"}]},"_chembl":{"chemblId":"CHEMBL4297812","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Povidone-iodine (the active ingredient in Betadine) releases free iodine when applied topically, which penetrates microbial cell membranes and denatures essential proteins and DNA/RNA. This broad-spectrum antimicrobial action is effective against bacteria, viruses, fungi, and some protozoa. The solution is used preoperatively to reduce the microbial load on the ocular surface and surrounding tissues, thereby reducing the risk of surgical site infections.","oneSentence":"Betadine ophthalmic prep solution is an iodine-based antiseptic that kills microorganisms through oxidative damage to cellular proteins and nucleic acids.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:04:02.793Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Preoperative antiseptic preparation of the ocular surface and periocular skin prior to ophthalmic surgery"}]},"trialDetails":[{"nctId":"NCT01531699","phase":"PHASE3","title":"Antimicrobial Efficacy of ALT005 Ophthalmic Prep Solution in Healthy Volunteers","status":"COMPLETED","sponsor":"Altacor Ltd.","startDate":"2012-02","conditions":"Infection Secondary to Surgical Procedure","enrollment":54},{"nctId":"NCT03349515","phase":"PHASE4","title":"The Effect of Povidone-iodine Ophthalmic Surgical Prep Solution on Respiration in Children Undergoing Strabismus Surgery With General Anesthesia.","status":"COMPLETED","sponsor":"Medical University of South Carolina","startDate":"2017-11-02","conditions":"Strabismus","enrollment":106}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Betadine ophthalmic prep solution","genericName":"Betadine ophthalmic prep solution","companyName":"Altacor Ltd.","companyId":"altacor-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Betadine ophthalmic prep solution is an iodine-based antiseptic that kills microorganisms through oxidative damage to cellular proteins and nucleic acids. Used for Preoperative antiseptic preparation of the ocular surface and periocular skin prior to ophthalmic surgery.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}