{"id":"beta3-agonists-adrenergic-mirabegron-vibegron","safety":{"commonSideEffects":[{"rate":"2-4","effect":"Hypertension"},{"rate":"2-3","effect":"Headache"},{"rate":"2-3","effect":"Nasopharyngitis"},{"rate":"1-2","effect":"Urinary tract infection"},{"rate":"1-2","effect":"Dizziness"},{"rate":"1-2","effect":"Tachycardia"}]},"_chembl":{"chemblId":"CHEMBL2095212","moleculeType":"Small molecule","molecularWeight":"396.52"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Beta-3 adrenergic receptors are predominantly expressed in the bladder detrusor smooth muscle. Activation of these receptors triggers a signaling cascade that increases cAMP levels, leading to smooth muscle relaxation and reduced bladder contractions. This allows the bladder to store larger volumes of urine with fewer involuntary contractions, reducing urinary frequency and urgency.","oneSentence":"Beta-3 agonists activate beta-3 adrenergic receptors on the detrusor muscle of the bladder to increase muscle relaxation and increase bladder capacity.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:40:28.518Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Overactive bladder with symptoms of urge incontinence, urgency, and urinary frequency"},{"name":"Neurogenic detrusor overactivity (for vibegron)"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":41,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Beta3-Agonists, Adrenergic [Mirabegron/Vibegron]","genericName":"Beta3-Agonists, Adrenergic [Mirabegron/Vibegron]","companyName":"Women and Infants Hospital of Rhode Island","companyId":"women-and-infants-hospital-of-rhode-island","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Beta-3 agonists activate beta-3 adrenergic receptors on the detrusor muscle of the bladder to increase muscle relaxation and increase bladder capacity. Used for Overactive bladder with symptoms of urge incontinence, urgency, and urinary frequency, Neurogenic detrusor overactivity (for vibegron).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}