{"id":"beta-blockers-carvedilol-phosphate","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Dizziness"},{"rate":"10-15","effect":"Fatigue"},{"rate":"5-10","effect":"Bradycardia"},{"rate":"5-10","effect":"Hypotension"},{"rate":"5","effect":"Hyperglycemia"},{"rate":"<5","effect":"Bronchospasm"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Carvedilol is a third-generation beta blocker with additional alpha-1 blocking properties, which provides vasodilatory effects beyond typical beta blockade. It reduces sympathetic nervous system activity on the heart and blood vessels, decreasing myocardial oxygen demand and improving cardiac efficiency. The phosphate salt formulation enhances solubility and bioavailability compared to the free base.","oneSentence":"Carvedilol phosphate is a non-selective beta-adrenergic receptor antagonist that blocks beta-1 and beta-2 receptors to reduce heart rate, blood pressure, and cardiac workload.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:28:22.950Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension"},{"name":"Heart failure (systolic)"},{"name":"Left ventricular dysfunction post-myocardial infarction"},{"name":"Angina pectoris"}]},"trialDetails":[{"nctId":"NCT01009918","phase":"PHASE2","title":"Lisinopril or Coreg CR® in Reducing Side Effects in Women With Breast Cancer Receiving Trastuzumab","status":"COMPLETED","sponsor":"University of South Florida","startDate":"2010-03","conditions":"Breast Cancer, Cardiac Toxicity","enrollment":468},{"nctId":"NCT00273052","phase":"PHASE3","title":"COREG MR Versus TOPROL-XL On The Lipid Profile Of Normolipidemic Or Mildly Dyslipidemic Patients With Hypertension","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2006-01-05","conditions":"Hypertension","enrollment":514},{"nctId":"NCT00553969","phase":"PHASE1, PHASE2","title":"Efficacy of Coreg CR and Lisinopril on Markers for Cardiovascular Functional and Structural Disease","status":"COMPLETED","sponsor":"University of Minnesota","startDate":"2007-11","conditions":"Pre-hypertension","enrollment":101},{"nctId":"NCT03169426","phase":"PHASE4","title":"Effect of Beta-blocker on Cardioprotective Effect of Remote Ischemic Conditioning","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2017-05-17","conditions":"Myocardial Infarction","enrollment":11},{"nctId":"NCT00742508","phase":"PHASE1","title":"A Phase I/II Clinical Study of SK&F-105517-D in Japanese Patients With Chronic Heart Failure","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2008-08-28","conditions":"Heart Failure, Congestive","enrollment":41},{"nctId":"NCT00123903","phase":"PHASE3","title":"COREG MR Versus TOPROL-XL On Reduction Of Microalbuminuria In Patients With Hypertension And Microalbuminuria","status":"TERMINATED","sponsor":"GlaxoSmithKline","startDate":"2005-07","conditions":"Heart Failure, Congestive and Microalbuminuria","enrollment":1220}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Beta Blockers Carvedilol Phosphate","genericName":"Beta Blockers Carvedilol Phosphate","companyName":"Seoul National University Hospital","companyId":"seoul-national-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Carvedilol phosphate is a non-selective beta-adrenergic receptor antagonist that blocks beta-1 and beta-2 receptors to reduce heart rate, blood pressure, and cardiac workload. Used for Hypertension, Heart failure (systolic), Left ventricular dysfunction post-myocardial infarction.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}