{"id":"beta-blocker-aspirin-clopidogrel","safety":{"commonSideEffects":[{"rate":"2-5","effect":"Bleeding"},{"rate":"5-10","effect":"Bradycardia"},{"rate":"5-15","effect":"Fatigue"},{"rate":"3-8","effect":"Dyspnea"},{"rate":"1-3","effect":"Gastrointestinal bleeding"},{"rate":"3-7","effect":"Hypotension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Beta blockers work by blocking beta-adrenergic receptors to decrease heart rate, contractility, and blood pressure. Aspirin irreversibly inhibits cyclooxygenase (COX) to prevent thromboxane A2 production and platelet aggregation. Clopidogrel is a P2Y12 receptor antagonist that prevents ADP-induced platelet activation. Together, these agents reduce the risk of myocardial infarction, stent thrombosis, and stroke in cardiovascular disease.","oneSentence":"This is a combination therapy that reduces heart rate and blood pressure (beta blocker) while inhibiting platelet aggregation and clot formation (aspirin and clopidogrel) to prevent cardiovascular events.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:28:24.073Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute coronary syndrome"},{"name":"Secondary prevention after myocardial infarction"},{"name":"Prevention of stent thrombosis"},{"name":"Stroke prevention in cardiovascular disease"}]},"trialDetails":[{"nctId":"NCT07349979","phase":"NA","title":"PCI With Guideline-Directed Medical Therapy for HFpEF Patients With Ischemic Cardiomyopathy","status":"NOT_YET_RECRUITING","sponsor":"Nanjing First Hospital, Nanjing Medical University","startDate":"2026-01-30","conditions":"Heart Failure With Reduced Ejection Fraction, Coronary Artery Disease","enrollment":654},{"nctId":"NCT05122780","phase":"PHASE4","title":"Prognostic Value of Precision Medicine in Patients With MINOCA (PROMISE Trial).","status":"ACTIVE_NOT_RECRUITING","sponsor":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","startDate":"2021-07-01","conditions":"Myocardial Infarction With Non-Obstructive Coronary Arteries","enrollment":120},{"nctId":"NCT05045274","phase":"NA","title":"The Effect of Early Administration of Dapagliflozin in STEMI Patients With LV Systolic Dysfunction","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2021-12","conditions":"STEMI - ST Elevation Myocardial Infarction, Left Ventricular Systolic Dysfunction","enrollment":300},{"nctId":"NCT04850417","phase":"PHASE4","title":"Randomized Study of Beta-Blockers and Antiplatelets in Patients With Spontaneous Coronary Artery Dissection","status":"NOT_YET_RECRUITING","sponsor":"Spanish Society of Cardiology","startDate":"2021-04-30","conditions":"Spontaneous Coronary Artery Dissection","enrollment":600},{"nctId":"NCT04744571","phase":"NA","title":"Safety and Efficacy of Drug-Coated Balloon Angioplasty for the Treatment of Chronic Total Occlusions","status":"UNKNOWN","sponsor":"Beijing Anzhen Hospital","startDate":"2021-02","conditions":"Coronary Artery Disease, Coronary Occlusion, Percutaneous Coronary Intervention","enrollment":200},{"nctId":"NCT02086019","phase":"NA","title":"Revascularisation or Medical Therapy in Elderly Patients With Acute Anginal Syndromes","status":"COMPLETED","sponsor":"Brighton and Sussex University Hospitals NHS Trust","startDate":"2014-05-01","conditions":"Acute Coronary Syndromes","enrollment":250},{"nctId":"NCT03372785","phase":"","title":"The Success of Opening Concurrent CTO leSion to Improve Cardiac Function Trial in Patients With Multi-vessel Disease","status":"UNKNOWN","sponsor":"Beijing Anzhen Hospital","startDate":"2018-04-10","conditions":"Chronic Total Occlusion of Coronary Artery, Percutaneous Coronary Intervention, Coronary Artery Disease","enrollment":240},{"nctId":"NCT04434365","phase":"PHASE1, PHASE2","title":"Effect of Berberine for Endothelial Function and Intestinal Microflora in Patients With Coronary Artery Disease","status":"UNKNOWN","sponsor":"Peking Union Medical College Hospital","startDate":"2019-06-21","conditions":"Stable Coronary Artery Disease, Percutaneous Coronary Intervention","enrollment":24},{"nctId":"NCT02767401","phase":"PHASE4","title":"The Success of Opening Single CTO Lesions to Improve Myocardial Viability Study (SOS-comedy)","status":"COMPLETED","sponsor":"The First Affiliated Hospital of Dalian Medical University","startDate":"2015-09-15","conditions":"Hibernation, Myocardial, Complete Occlusion of Coronary Artery","enrollment":200},{"nctId":"NCT00968383","phase":"NA","title":"Cardiovascular Magnetic Resonance for the Occluded Infarct-Related Artery Treatment","status":"TERMINATED","sponsor":"National Institute of Cardiology, Warsaw, Poland","startDate":"2009-09","conditions":"Cardiovascular Diseases, Heart Diseases, Myocardial Infarction","enrollment":11}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":59,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Beta-blockers","Aspirin","Clopidogrel"],"phase":"marketed","status":"active","brandName":"Beta blocker, aspirin, clopidogrel","genericName":"Beta blocker, aspirin, clopidogrel","companyName":"Spanish Society of Cardiology","companyId":"spanish-society-of-cardiology","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Beta blockers, such as betaloc, are used to treat conditions like coronary artery disease and myocardial conditions. Aspirin and clopidogrel are antiplatelet medications used in conjunction with stenting or balloon expansion to prevent blood clots in patients with coronary artery disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}