{"id":"beta-1-3-glucan","safety":{"commonSideEffects":[{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Mild gastrointestinal disturbance"}]},"_chembl":{"chemblId":"CHEMBL243373","moleculeType":"Small molecule","molecularWeight":"424.40"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Beta-1,3-glucan is a fungal cell wall-derived polysaccharide that binds to pattern recognition receptors (such as Dectin-1) on immune cells, triggering innate immune activation. This leads to enhanced phagocytosis, cytokine production, and natural killer cell activity, supporting immune surveillance against pathogens and potentially malignant cells.","oneSentence":"Beta-1,3-glucan is a polysaccharide that activates innate immune cells, particularly macrophages and neutrophils, to enhance immune response and promote anti-tumor or anti-infection activity.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:42:58.267Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cancer immunotherapy (adjunctive)"},{"name":"Immune enhancement in infectious diseases"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"DEHYDRATION"},{"count":1,"reaction":"DIARRHOEA"},{"count":1,"reaction":"FEBRILE NEUTROPENIA"},{"count":1,"reaction":"GASTRITIS"},{"count":1,"reaction":"HYPERTENSION"},{"count":1,"reaction":"HYPONATRAEMIA"},{"count":1,"reaction":"NEUTROPENIA"},{"count":1,"reaction":"TRANSAMINASES INCREASED"}],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"beta-1,3-glucan","genericName":"beta-1,3-glucan","companyName":"Meiji University of Oriental Medicine","companyId":"meiji-university-of-oriental-medicine","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Beta-1,3-glucan is a polysaccharide that activates innate immune cells, particularly macrophages and neutrophils, to enhance immune response and promote anti-tumor or anti-infection activity. Used for Cancer immunotherapy (adjunctive), Immune enhancement in infectious diseases.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}