{"id":"berlim-25-20-association","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Hyperkalemia (losartan component)"},{"rate":null,"effect":"Hypokalemia (hydrochlorothiazide component)"},{"rate":null,"effect":"Hyperuricemia"},{"rate":null,"effect":"Hyperglycemia"}]},"_chembl":{"chemblId":"CHEMBL5779297","moleculeType":null,"molecularWeight":"516.99"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Losartan blocks angiotensin II type 1 receptors, preventing vasoconstriction and aldosterone secretion, while hydrochlorothiazide acts as a thiazide diuretic to reduce blood volume and sodium reabsorption. The combination provides synergistic antihypertensive effects with complementary mechanisms of action.","oneSentence":"BERLIM 25/20 is a fixed-dose combination of losartan (angiotensin II receptor antagonist) and hydrochlorothiazide (thiazide diuretic) that reduces blood pressure through dual antihypertensive pathways.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:04:00.635Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Essential hypertension"}]},"trialDetails":[{"nctId":"NCT04602754","phase":"PHASE3","title":"Efficacy and Safety of Berlim 25/20 Association in the Treatment of Type II Diabetes Mellitus and Dyslipidemia.","status":"RECRUITING","sponsor":"EMS","startDate":"2023-12-01","conditions":"Dyslipidemia Associated With Type II Diabetes Mellitus","enrollment":228}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"BERLIM 25/20 ASSOCIATION","genericName":"BERLIM 25/20 ASSOCIATION","companyName":"EMS","companyId":"ems","modality":"Small molecule","firstApprovalDate":"","aiSummary":"BERLIM 25/20 is a fixed-dose combination of losartan (angiotensin II receptor antagonist) and hydrochlorothiazide (thiazide diuretic) that reduces blood pressure through dual antihypertensive pathways. Used for Essential hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}