{"id":"berberine-atorvastatin-or-rosuvastatin","safety":{"commonSideEffects":[{"rate":null,"effect":"Muscle pain or myalgia"},{"rate":null,"effect":"Elevated liver enzymes"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Berberine activates AMP-activated protein kinase (AMPK) and upregulates LDL receptor expression, improving cholesterol clearance. When combined with statins, which directly inhibit the rate-limiting enzyme in cholesterol synthesis, the dual mechanism provides synergistic reduction in serum LDL cholesterol and triglycerides. This combination targets hyperlipidemia through complementary pathways.","oneSentence":"This combination uses berberine to enhance lipid metabolism and reduce cholesterol synthesis, paired with a statin (atorvastatin or rosuvastatin) to inhibit HMG-CoA reductase for additive LDL-lowering effects.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:28:22.097Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hyperlipidemia and dyslipidemia management"},{"name":"Cardiovascular risk reduction in patients with elevated cholesterol"}]},"trialDetails":[{"nctId":"NCT04434365","phase":"PHASE1, PHASE2","title":"Effect of Berberine for Endothelial Function and Intestinal Microflora in Patients With Coronary Artery Disease","status":"UNKNOWN","sponsor":"Peking Union Medical College Hospital","startDate":"2019-06-21","conditions":"Stable Coronary Artery Disease, Percutaneous Coronary Intervention","enrollment":24},{"nctId":"NCT01697735","phase":"PHASE4","title":"The Therapeutic Effects of Statins and Berberine on the Hyperlipemia","status":"TERMINATED","sponsor":"Wenzhou Medical University","startDate":"2012-09","conditions":"Dyslipidemias","enrollment":24}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Berberine;","Liptor","Crestor"],"phase":"marketed","status":"active","brandName":"Berberine;Atorvastatin or Rosuvastatin","genericName":"Berberine;Atorvastatin or Rosuvastatin","companyName":"Wenzhou Medical University","companyId":"wenzhou-medical-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination uses berberine to enhance lipid metabolism and reduce cholesterol synthesis, paired with a statin (atorvastatin or rosuvastatin) to inhibit HMG-CoA reductase for additive LDL-lowering effects. Used for Hyperlipidemia and dyslipidemia management, Cardiovascular risk reduction in patients with elevated cholesterol.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}