{"id":"beraprost","rwe":[],"tags":[{"label":"beraprost","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Prostacyclin receptor","category":"target"},{"label":"PTGIR","category":"gene"},{"label":"PTGER3","category":"gene"},{"label":"PTGER4","category":"gene"},{"label":"B01AC19","category":"atc"},{"label":"Active","category":"status"},{"label":"Pulmonary arterial hypertension","category":"indication"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Hematologic Agents","category":"pharmacology"},{"label":"Platelet Aggregation Inhibitors","category":"pharmacology"},{"label":"Vasodilator Agents","category":"pharmacology"}],"phase":"discontinued","safety":{"safetySignals":[{"llr":196.734,"date":"","count":65,"signal":"Right ventricular failure","source":"DrugCentral FAERS","actionTaken":"Reported 65 times (LLR=197)"},{"llr":181.394,"date":"","count":54,"signal":"Concomitant disease aggravated","source":"DrugCentral FAERS","actionTaken":"Reported 54 times (LLR=181)"},{"llr":175.39,"date":"","count":108,"signal":"Cardiac failure","source":"DrugCentral FAERS","actionTaken":"Reported 108 times (LLR=175)"},{"llr":164.666,"date":"","count":71,"signal":"Pulmonary hypertension","source":"DrugCentral FAERS","actionTaken":"Reported 71 times (LLR=165)"},{"llr":126.057,"date":"","count":38,"signal":"Brain natriuretic peptide increased","source":"DrugCentral FAERS","actionTaken":"Reported 38 times (LLR=126)"},{"llr":91.444,"date":"","count":39,"signal":"Pulmonary arterial hypertension","source":"DrugCentral FAERS","actionTaken":"Reported 39 times (LLR=91)"},{"llr":87.377,"date":"","count":52,"signal":"Hepatic function abnormal","source":"DrugCentral FAERS","actionTaken":"Reported 52 times (LLR=87)"},{"llr":84.772,"date":"","count":23,"signal":"Upper respiratory tract inflammation","source":"DrugCentral FAERS","actionTaken":"Reported 23 times (LLR=85)"},{"llr":83.459,"date":"","count":34,"signal":"Transfusion","source":"DrugCentral FAERS","actionTaken":"Reported 34 times (LLR=83)"},{"llr":79.466,"date":"","count":111,"signal":"Anaemia","source":"DrugCentral FAERS","actionTaken":"Reported 111 times (LLR=79)"},{"llr":66.15,"date":"","count":31,"signal":"Iron deficiency anaemia","source":"DrugCentral FAERS","actionTaken":"Reported 31 times (LLR=66)"},{"llr":61.403,"date":"","count":65,"signal":"Platelet count decreased","source":"DrugCentral FAERS","actionTaken":"Reported 65 times (LLR=61)"},{"llr":47.273,"date":"","count":32,"signal":"Gamma-glutamyltransferase increased","source":"DrugCentral FAERS","actionTaken":"Reported 32 times (LLR=47)"},{"llr":45.3,"date":"","count":46,"signal":"Aspartate aminotransferase increased","source":"DrugCentral FAERS","actionTaken":"Reported 46 times (LLR=45)"},{"llr":45.121,"date":"","count":40,"signal":"Blood pressure decreased","source":"DrugCentral FAERS","actionTaken":"Reported 40 times (LLR=45)"}],"commonSideEffects":[{"effect":"Right ventricular failure","drugRate":"LLR 197","severity":"common"},{"effect":"Concomitant disease aggravated","drugRate":"LLR 181","severity":"common"},{"effect":"Cardiac failure","drugRate":"LLR 175","severity":"common"},{"effect":"Pulmonary hypertension","drugRate":"LLR 165","severity":"common"},{"effect":"Brain natriuretic peptide increased","drugRate":"LLR 126","severity":"common"},{"effect":"Pulmonary arterial hypertension","drugRate":"LLR 91","severity":"common"},{"effect":"Hepatic function abnormal","drugRate":"LLR 87","severity":"common"},{"effect":"Upper respiratory tract inflammation","drugRate":"LLR 85","severity":"common"},{"effect":"Transfusion","drugRate":"LLR 83","severity":"common"},{"effect":"Anaemia","drugRate":"LLR 79","severity":"common"},{"effect":"Platelet count decreased","drugRate":"LLR 61","severity":"common"},{"effect":"Gamma-glutamyltransferase increased","drugRate":"LLR 47","severity":"common"},{"effect":"Aspartate aminotransferase increased","drugRate":"LLR 45","severity":"common"},{"effect":"Blood pressure decreased","drugRate":"LLR 45","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"procylin","offLabel":[],"synonyms":["procylin","beraprost sodium","beraprost"],"timeline":[{"date":"1992-01-01","type":"positive","source":"DrugCentral","milestone":"YEAR INTRODUCED approval"}],"brandName":"Procylin","ecosystem":[{"indication":"Pulmonary arterial hypertension","otherDrugs":[{"name":"ambrisentan","slug":"ambrisentan","company":"Gilead"},{"name":"bosentan","slug":"bosentan","company":"Actelion Pharms Ltd"},{"name":"epoprostenol","slug":"epoprostenol","company":"Glaxosmithkline Llc"},{"name":"iloprost","slug":"iloprost","company":"Actelion Pharms Ltd"}],"globalPrevalence":1280000000}],"mechanism":{"target":"Prostacyclin receptor","targets":[{"gene":"PTGIR","source":"DrugCentral","target":"Prostacyclin 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Prostacyclin is a natural key that helps to relax blood vessels and improve blood flow. Procylin is a man-made key that works in a similar way, helping to open up the blood vessels and make it easier for blood to flow through them.","oneSentence":"Procylin works by activating the prostacyclin receptor, which helps to relax blood vessels and improve blood flow.","technicalDetail":"Procylin is a selective agonist of the IP receptor, which is a subtype of the prostacyclin receptor. By activating this receptor, Procylin stimulates the production of cyclic AMP, leading to vasodilation and improved blood flow."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/343","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=BERAPROST","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BERAPROST","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:59:52.202808","biosimilars":[],"competitors":[{"drugName":"clopidogrel","drugSlug":"clopidogrel","fdaApproval":"1997-11-17","genericCount":23,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ticlopidine","drugSlug":"ticlopidine","fdaApproval":"1991-10-31","genericCount":8,"patentStatus":"Off-patent — generic 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prostacyclin receptor. It is used to treat pulmonary arterial hypertension, a condition characterized by high blood pressure in the arteries of the lungs. The commercial status of Procylin is unclear, but it is likely patented. Key safety considerations include the potential for adverse effects such as headache and flushing. Procylin works by mimicking the action of prostacyclin, a natural substance that helps to relax blood vessels and improve blood flow.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}