{"id":"bepotastine-besilate-formulation","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Taste perversion"},{"rate":null,"effect":"Conjunctival hyperemia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bepotastine competitively antagonizes H1 histamine receptors on mast cells and other immune cells, preventing histamine-mediated allergic responses. It is formulated as an ophthalmic solution for topical ocular administration, where it rapidly penetrates the eye to provide local anti-allergic effects with minimal systemic absorption.","oneSentence":"Bepotastine besilate is a selective H1-receptor antagonist that blocks histamine signaling to reduce allergic symptoms.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:04:02.074Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic conjunctivitis"}]},"trialDetails":[{"nctId":"NCT01578278","phase":"PHASE2","title":"Bepotastine Besilate-corticosteroid Nasal Spray Combination Compared to Placebo, Bepotastine Besilate Nasal Spray, and Corticosteroid Nasal Spray in the Treatment of Patients With Seasonal Allergic Rhinitis","status":"COMPLETED","sponsor":"Bausch & Lomb Incorporated","startDate":"2011-12","conditions":"Seasonal Allergic Rhinitis","enrollment":606},{"nctId":"NCT01443442","phase":"PHASE4","title":"Bepreve vs. Alrex in Subjects With Moderate to Severe Allergic Conjunctivitis","status":"COMPLETED","sponsor":"Southern California College of Optometry at Marshall B. Ketchum University","startDate":"2011-10","conditions":"Allergic Conjunctivitis","enrollment":23}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["TALION 5mg tablets","PRO-172"],"phase":"phase_3","status":"active","brandName":"Bepotastine besilate formulation","genericName":"Bepotastine besilate formulation","companyName":"Bausch & Lomb Incorporated","companyId":"bausch-lomb-incorporated","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bepotastine besilate is a selective H1-receptor antagonist that blocks histamine signaling to reduce allergic symptoms. Used for Allergic conjunctivitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}