{"id":"bephenium","rwe":[{"pmid":"35378899","year":"2022","title":"Acyl-CoA Binding Domain Containing 4 Polymorphism rs4986172 and Expression Can Serve as Overall Survival Biomarkers for Hepatitis B Virus-Related Hepatocellular Carcinoma Patients After Hepatectomy.","finding":"","journal":"Pharmacogenomics and personalized medicine","studyType":"Clinical Study"},{"pmid":"33860255","year":"2021","title":"Interaction of agonists of a different subtype of the nAChR and carvacrol with GABA in Ascaris suum somatic muscle contractions.","finding":"","journal":"Journal of nematology","studyType":"Clinical Study"},{"pmid":"32032866","year":"2020","title":"Carvacrol acts as a potent selective antagonist of different types of nicotinic acetylcholine receptors and enhances the effect of monepantel in the parasitic nematode Ascaris suum.","finding":"","journal":"Veterinary parasitology","studyType":"Clinical Study"},{"pmid":"30190363","year":"2018","title":"Activation of Caenorhabditis elegans Levamisole-Sensitive and Mammalian Nicotinic Receptors by the Antiparasitic Bephenium.","finding":"","journal":"Molecular pharmacology","studyType":"Clinical Study"},{"pmid":"28487481","year":"2017","title":"Functional genomics in Brugia malayi reveal diverse muscle nAChRs and differences between cholinergic anthelmintics.","finding":"","journal":"Proceedings of the National Academy of Sciences of the United States of America","studyType":"Clinical Study"}],"tags":[{"label":"bephenium","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"P02CX02","category":"atc"},{"label":"Active","category":"status"},{"label":"Anthelmintics","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Antiparasitic Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["bephenium","bephenium hydroxynaphthoate"],"offLabel":[],"synonyms":["bephenium","bephenium hydroxynaphthoate"],"timeline":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"bephenium","explanation":"Imagine bephenium as a key that fits into a specific lock in the body, allowing it to turn on or off certain cellular processes. This can help to regulate various bodily functions, but the exact details of how it works are not well understood. More research is needed to fully understand bephenium's mechanism of action.","oneSentence":"Bephenium is thought to work by modulating the activity of certain enzymes or receptors in the body.","technicalDetail":"Bephenium is believed to exert its effects through interaction with specific molecular targets, potentially influencing enzyme activity or receptor signaling pathways."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/340","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=bephenium","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:57:49.068851","biosimilars":[],"competitors":[{"drugName":"pyrvinium","drugSlug":"pyrvinium","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"moxidectin","drugSlug":"moxidectin","fdaApproval":"2018-06-13","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"bephenium","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"pyrvinium","brandName":"pyrvinium","genericName":"pyrvinium","approvalYear":"","relationship":"same-class"},{"drugId":"moxidectin","brandName":"moxidectin","genericName":"moxidectin","approvalYear":"2018","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"002983","UNII":"PXO9B4983I","CHEBI":"CHEBI:135055","INN_ID":"876","UMLSCUI":"C0356357","ChEMBL_ID":"CHEMBL1788404","DRUGBANK_ID":"DB13462","PUBCHEM_CID":"19667","SNOMEDCT_US":"324989001","SECONDARY_CAS_RN":"3818-50-6","MESH_SUPPLEMENTAL_RECORD_UI":"C006739"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":142,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"P02CX02","allCodes":["P02CX02"]},"biosimilarFilings":[],"recentPublications":[{"date":"2022","pmid":"35378899","title":"Acyl-CoA Binding Domain Containing 4 Polymorphism rs4986172 and Expression Can Serve as Overall Survival Biomarkers for Hepatitis B Virus-Related Hepatocellular Carcinoma Patients After Hepatectomy.","journal":"Pharmacogenomics and personalized medicine"},{"date":"2021","pmid":"33860255","title":"Interaction of agonists of a different subtype of the nAChR and carvacrol with GABA in Ascaris suum somatic muscle contractions.","journal":"Journal of nematology"},{"date":"2020 Feb","pmid":"32032866","title":"Carvacrol acts as a potent selective antagonist of different types of nicotinic acetylcholine receptors and enhances the effect of monepantel in the parasitic nematode Ascaris suum.","journal":"Veterinary parasitology"},{"date":"2018 Nov","pmid":"30190363","title":"Activation of Caenorhabditis elegans Levamisole-Sensitive and Mammalian Nicotinic Receptors by the Antiparasitic Bephenium.","journal":"Molecular pharmacology"},{"date":"2017 May 23","pmid":"28487481","title":"Functional genomics in Brugia malayi reveal diverse muscle nAChRs and differences between cholinergic anthelmintics.","journal":"Proceedings of the National Academy of Sciences of the United States of America"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"bephenium","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Bephenium is a small molecule used as an anthelmintic agent. It is indicated for the treatment of hookworm infections and ascariasis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}