{"id":"benzylsulfamide","rwe":[],"tags":[{"label":"benzylsulfamide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Carbonic anhydrase 9","category":"target"},{"label":"CA9","category":"gene"},{"label":"CA12","category":"gene"},{"label":"CA2","category":"gene"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"_fixedAt":"2026-03-30T16:37:49.294606","allNames":"benzylsulfanilamide","offLabel":[],"synonyms":["benzylsulfamide","benzylsulfanilamide"],"timeline":[],"brandName":"Benzylsulfanilamide","ecosystem":[],"mechanism":{"target":"Carbonic anhydrase 1, Carbonic anhydrase 12, Carbonic anhydrase 2","targets":[{"gene":"CA9","source":"DrugCentral","target":"Carbonic anhydrase 9","protein":"Carbonic anhydrase 9"},{"gene":"CA12","source":"DrugCentral","target":"Carbonic anhydrase 12","protein":"Carbonic anhydrase 12"},{"gene":"CA2","source":"DrugCentral","target":"Carbonic anhydrase 2","protein":"Carbonic anhydrase 2"},{"gene":"CA1","source":"DrugCentral","target":"Carbonic anhydrase 1","protein":"Carbonic anhydrase 1"}],"modality":"Small Molecule","drugClass":"benzylsulfamide","explanation":"Think of carbonic anhydrase 9 like a construction crew that helps build new roads for cancer cells to grow and spread. By blocking this crew, benzylsulfanilamide can slow down the growth of tumors and prevent them from spreading to other parts of the body.","oneSentence":"Benzylsulfanilamide works by inhibiting the enzyme carbonic anhydrase 9, which is involved in the growth and spread of cancer cells.","technicalDetail":"Benzylsulfanilamide acts as a competitive inhibitor of carbonic anhydrase 9, binding to the enzyme's active site and preventing the conversion of carbon dioxide to bicarbonate, which is essential for tumor growth and metastasis."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3686","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BENZYLSULFAMIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:59:40.291915","biosimilars":[],"competitors":[{"drugName":"acetazolamide","drugSlug":"acetazolamide","fdaApproval":"1953-07-27","genericCount":29,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"acetohydroxamic 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Oct","pmid":"25159522","title":"Carbonic anhydrase inhibitory properties of novel benzylsulfamides using molecular modeling and experimental studies.","journal":"Bioorganic chemistry"},{"date":"2011 Jun 1","pmid":"21754910","title":"Benzyl-sulfamide.","journal":"Acta crystallographica. Section E, Structure reports online"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Benzylsulfanilamide is a small molecule. Its mechanism of action is not specified in the provided information.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}