{"id":"benzylhydrochlorothiazide","rwe":[],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Congestive heart failure","category":"indication"},{"label":"Hypertensive disorder","category":"indication"},{"label":"Malignant hypertension","category":"indication"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"_fixedAt":"2026-03-30T16:37:28.606510","allNames":"behyd","offLabel":[],"synonyms":["benzylhydrochlorothiazide","benclortriazide","benzclortriazide","behyd"],"timeline":[],"brandName":"Behyd","ecosystem":[{"indication":"Congestive heart failure","otherDrugs":[{"name":"acetyldigitoxin","slug":"acetyldigitoxin","company":"Novartis"},{"name":"enalapril","slug":"enalapril","company":"Valeant Pharms North"},{"name":"enalaprilat","slug":"enalaprilat","company":"Biovail Labs Intl"},{"name":"ubidecarenone","slug":"ubidecarenone","company":""}],"globalPrevalence":64000000},{"indication":"Hypertensive disorder","otherDrugs":[{"name":"acebutolol","slug":"acebutolol","company":"Promius Pharma"},{"name":"aliskiren","slug":"aliskiren","company":"Novartis"},{"name":"amiloride","slug":"amiloride","company":"Paddock Llc"},{"name":"amlodipine","slug":"amlodipine","company":"Pfizer"}],"globalPrevalence":null},{"indication":"Malignant hypertension","otherDrugs":[],"globalPrevalence":1280000000}],"mechanism":{"modality":"Small Molecule","explanation":"Think of it like a sponge: when you squeeze a sponge, water comes out. Behyd helps the kidneys squeeze out excess water and salt from the blood, which reduces blood pressure and helps the heart work more efficiently.","oneSentence":"Behyd works by blocking sodium reabsorption in the kidneys, which increases urine production and reduces blood pressure.","technicalDetail":"Behyd acts as a thiazide diuretic, inhibiting the sodium-chloride cotransporter (NCC) in the distal convoluted tubule of the kidneys, leading to increased sodium and chloride excretion and subsequent diuresis."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/336","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=benzylhydrochlorothiazide","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:59:37.440965","biosimilars":[],"competitors":[],"genericName":"benzylhydrochlorothiazide","indications":{"approved":[{"name":"Congestive heart failure","source":"DrugCentral","snomedId":42343007,"regulator":"FDA","usPrevalence":6200000,"globalPrevalence":64000000,"prevalenceMethod":"curated","prevalenceSource":"ESC Heart Failure, 2023"},{"name":"Hypertensive disorder","source":"DrugCentral","snomedId":38341003,"regulator":"FDA"},{"name":"Malignant hypertension","source":"DrugCentral","snomedId":70272006,"regulator":"FDA","usPrevalence":119900000,"globalPrevalence":1280000000,"prevalenceMethod":"curated","prevalenceSource":"WHO, 2023"}],"offLabel":[],"pipeline":[]},"_fixedFields":["pubmed(10)"],"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"008191","UNII":"176437APQH","CHEBI":"CHEBI:31269","UMLSCUI":"C0621906","ChEMBL_ID":"CHEMBL1562084","KEGG_DRUG":"D01246","PUBCHEM_CID":"2348","MESH_SUPPLEMENTAL_RECORD_UI":"C042169"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":10,"therapeuticAreas":["Cardiovascular"],"biosimilarFilings":[],"recentPublications":[{"date":"1997 Sep","pmid":"9342417","title":"Evaluation of phototoxic properties of oral antidiabetics and diuretics. Photohemolysis model as a screening method for recognizing potential photosensitizing drugs.","journal":"Arzneimittel-Forschung"},{"date":"1997 Sep","pmid":"9303564","title":"Cell cultures in the investigation of thiazide phototoxicity.","journal":"Naunyn-Schmiedeberg's archives of pharmacology"},{"date":"1997 Mar","pmid":"9134756","title":"Inhibiting effects of antioxidants on drug-induced phototoxicity in cell cultures. Investigations with sulphonamide-derived oral antidiabetics and diuretics.","journal":"Journal of photochemistry and photobiology. B, Biology"},{"date":"1997 Feb-Apr","pmid":"9361121","title":"Phototoxicity to sulphonamide-derived oral antidiabetics and diuretics: investigations in hairless mice.","journal":"Photodermatology, photoimmunology & photomedicine"},{"date":"1997 Jan-Feb","pmid":"9067780","title":"Phototoxicity to sulphonamide derived oral antidiabetics and diuretics. Comparative in vitro and in vivo investigations.","journal":"In vivo (Athens, Greece)"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Behyd (benzylhydrochlorothiazide) is a small molecule modality used to treat congestive heart failure, hypertensive disorder, and malignant hypertension. Although its exact target and drug class are unknown, it is believed to work by inhibiting sodium reabsorption in the kidneys, leading to increased urine production and reduced blood pressure. Behyd is not currently listed as a patented or off-patent medication, and its commercial status is unclear. Further research is needed to fully understand its pharmacological properties and clinical applications. As a result, key safety considerations and dosing information are not well established.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}