{"id":"benzyl-nicotinate","rwe":[],"tags":[{"label":"benzyl nicotinate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"rubriment","offLabel":[],"synonyms":["nicotinic acid benzyl ester","benzyl nicotinate","benzyl pyridine-3-carboxylate","niacin benzyl ester","rubriment"],"timeline":[],"brandName":"Rubriment","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"benzyl nicotinate","explanation":"Think of it like a key that unlocks the blood vessels, allowing them to relax and widen. This helps improve blood flow to the skin, which can be beneficial for people with certain skin conditions. By improving blood flow, benzyl nicotinate can help reduce inflammation and promote healing.","oneSentence":"Benzyl nicotinate works by stimulating the release of nitric oxide, which causes blood vessels to dilate and improves blood flow.","technicalDetail":"Benzyl nicotinate acts as a vasodilator by stimulating the release of nitric oxide from endothelial cells, leading to the activation of guanylate cyclase and the subsequent increase in cyclic guanosine monophosphate (cGMP) levels, resulting in smooth muscle relaxation and vasodilation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3379","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=benzyl nicotinate","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:57:41.618992","biosimilars":[],"competitors":[],"genericName":"benzyl nicotinate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"MMSL":"2275","NDDF":"001052","UNII":"S497LCF9C9","CHEBI":"CHEBI:31268","VANDF":"4017661","RXNORM":"31767","UMLSCUI":"C0068724","ChEMBL_ID":"CHEMBL209744","KEGG_DRUG":"D01419","DRUGBANK_ID":"DB15764","PDB_CHEM_ID":" 0OM","PUBCHEM_CID":"7191","SNOMEDCT_US":"273943001","MESH_SUPPLEMENTAL_RECORD_UI":"C025653"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":29,"therapeuticAreas":["Hematology"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Rubriment, also known as benzyl nicotinate, is a small molecule drug in the benzyl nicotinate class. Its exact target and mechanism of action are unknown, but it is believed to work by dilating blood vessels and improving blood flow. It is not FDA-approved for any indications, and its commercial status, including patent and generic availability, is unclear. Further research is needed to fully understand its safety and efficacy. As a result, it is not widely used in clinical practice.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}