{"id":"benzyl-alcohol-lotion-5","safety":{"commonSideEffects":[{"rate":null,"effect":"Scalp irritation"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Contact dermatitis"}]},"_chembl":null,"_fixedAt":"2026-03-30T14:07:01.703454","_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Benzyl alcohol is a topical agent that paralyzes and kills head lice (Pediculus humanus capitis) and their nits by interfering with their neuromuscular function. The 5% lotion formulation allows for direct contact with lice and eggs on the scalp and hair. It is believed to work through a mechanism distinct from traditional neurotoxic insecticides, making it potentially useful for lice resistant to conventional treatments.","oneSentence":"Benzyl alcohol acts as a pediculicide and ovicide by disrupting the nervous system of lice and their eggs through neurotoxic effects.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:04:02.077Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Head lice infestation (Pediculus humanus capitis)"}]},"_fixedFields":["pubmed(5)"],"trialDetails":[{"nctId":"NCT02624843","phase":"PHASE3","title":"Bioequivalence Study for Benzyl Alcohol Lotion 5%.","status":"COMPLETED","sponsor":"Akorn, Inc.","startDate":"2015-08","conditions":"Head Lice","enrollment":239}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"recentPublications":[{"date":"2023 Apr 5","pmid":"36849039","title":"Cosmeceutical formulations of pro-vitamin E phosphate: In-vitro release testing and dermal penetration into excised human skin.","journal":"International journal of pharmaceutics"},{"date":"2022 Jan-Feb 01","pmid":"34570737","title":"Patch Testing to Ethylhexylglycerin: The North American Contact Dermatitis Group Experience, 2013-2018.","journal":"Dermatitis : contact, atopic, occupational, drug"},{"date":"2013 Sep","pmid":"24259731","title":"Topical ivermectin 0.5% lotion for treatment of head lice.","journal":"The Annals of pharmacotherapy"},{"date":"2013 Mar-Apr","pmid":"23442453","title":"Insect bite reactions.","journal":"Indian journal of dermatology, venereology and leprology"},{"date":"2010 Jan-Feb","pmid":"20199404","title":"The clinical trials supporting benzyl alcohol lotion 5% (Ulesfia): a safe and effective topical treatment for head lice (pediculosis humanus capitis).","journal":"Pediatric dermatology"}],"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Benzyl Alcohol Lotion 5%","genericName":"Benzyl Alcohol Lotion 5%","companyName":"Akorn, Inc.","companyId":"akorn-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Benzyl alcohol acts as a pediculicide and ovicide by disrupting the nervous system of lice and their eggs through neurotoxic effects. Used for Head lice infestation (Pediculus humanus capitis).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}