{"id":"benzquinamide","rwe":[],"tags":[{"label":"benzquinamide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Prostaglandin G/H synthase 2","category":"target"},{"label":"PTGS2","category":"gene"},{"label":"ADRA2C","category":"gene"},{"label":"DRD4","category":"gene"},{"label":"Off-Patent","category":"patent"},{"label":"Active","category":"status"},{"label":"Postoperative nausea and vomiting","category":"indication"},{"label":"Approved 1970s","category":"decade"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=BENZQUINAMIDE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-19T23:49:23.959560+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-19T23:49:29.436487+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BENZQUINAMIDE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-19T23:49:29.887315+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201250/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-19T23:49:30.606646+00:00"}},"allNames":"emeticon","offLabel":[],"synonyms":["benzquinamide","benzquinamide hydrochloride","emeticon","promecon","benzquinamide HCl"],"timeline":[{"date":"1974-03-12","type":"positive","source":"DrugCentral","milestone":"FDA approval"}],"aiSummary":"Emeticon (BENZQUINAMIDE) is a small molecule drug that targets Prostaglandin G/H synthase 2. It was originally developed and is currently owned by a company not specified in the facts. Emeticon was FDA approved in 1974 for the treatment of postoperative nausea and vomiting. It is classified as a benzquinamide and is off-patent, meaning it is no longer protected by patents. Emeticon has a bioavailability of 36%.","brandName":"Emeticon","ecosystem":[{"indication":"Postoperative nausea and vomiting","otherDrugs":[{"name":"amisulpride","slug":"amisulpride","company":"Acacia Pharma Ltd"}],"globalPrevalence":null}],"mechanism":{"target":"Prostaglandin G/H synthase 2","novelty":"Follow-on","targets":[{"gene":"PTGS2","source":"DrugCentral","target":"Prostaglandin G/H synthase 2","protein":"Prostaglandin G/H synthase 2"},{"gene":"ADRA2C","source":"DrugCentral","target":"Alpha-2C adrenergic receptor","protein":"Alpha-2C adrenergic receptor"},{"gene":"DRD4","source":"DrugCentral","target":"D(4) dopamine receptor","protein":"D(4) dopamine receptor"},{"gene":"ADRA2B","source":"DrugCentral","target":"Alpha-2B adrenergic receptor","protein":"Alpha-2B adrenergic receptor"},{"gene":"ADRA2A","source":"DrugCentral","target":"Alpha-2A adrenergic receptor","protein":"Alpha-2A adrenergic receptor"},{"gene":"DRD3","source":"DrugCentral","target":"D(3) dopamine receptor","protein":"D(3) dopamine receptor"},{"gene":"DRD2","source":"DrugCentral","target":"D(2) dopamine receptor","protein":"D(2) dopamine receptor"}],"modality":"Small Molecule","drugClass":"benzquinamide","explanation":"","oneSentence":"","technicalDetail":"Emeticon specifically inhibits the cyclooxygenase-2 (COX-2) enzyme, which is involved in the conversion of arachidonic acid to prostaglandin H2, a key step in the production of prostaglandins."},"commercial":{"launchDate":"1974","_launchSource":"DrugCentral (FDA 1974-03-12, )"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/331","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BENZQUINAMIDE","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange Book"}],"_enrichedAt":"2026-03-30T08:59:25.459104","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-19T23:49:32.265486+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"aceclofenac","drugSlug":"aceclofenac","fdaApproval":"","relationship":"same-target"},{"drugName":"acetylsalicylic 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