{"id":"benzoyl-peroxide-and-sulfur","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation"},{"rate":null,"effect":"Dryness"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Peeling"},{"rate":null,"effect":"Contact dermatitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Benzoyl peroxide is a potent antimicrobial and keratolytic agent that generates reactive oxygen species to eliminate Cutibacterium acnes (formerly Propionibacterium acnes) and exfoliates dead skin cells. Sulfur acts as a mild keratolytic and antimicrobial agent that helps unclog pores and reduce sebaceous gland activity. Together, they address multiple pathogenic factors in acne formation.","oneSentence":"Benzoyl peroxide and sulfur work together to reduce acne by killing acne-causing bacteria, reducing sebum production, and promoting skin cell turnover.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:28:20.955Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"}]},"trialDetails":[{"nctId":"NCT02099240","phase":"EARLY_PHASE1","title":"Patients Response to Early Switch To Oral:Osteomyelitis Study","status":"TERMINATED","sponsor":"Julio Ramirez","startDate":"2014-03-06","conditions":"Osteomyelitis","enrollment":11},{"nctId":"NCT00964366","phase":"PHASE4","title":"Study to Determine and Compare the Tolerance and Irritation Potential of Topical Acne Medications","status":"COMPLETED","sponsor":"Stiefel, a GSK Company","startDate":"2009-07","conditions":"Acne Vulgaris","enrollment":53},{"nctId":"NCT01313728","phase":"PHASE4","title":"A Study That Evaluates the Decrease in Irritation When Using Additional Acne Treatment Products","status":"COMPLETED","sponsor":"Bausch Health Americas, Inc.","startDate":"2010-12","conditions":"Acne Vulgaris","enrollment":26},{"nctId":"NCT01260571","phase":"PHASE4","title":"Clinical Study to Evaluate the Efficacy of Topical Medications Containing Benzoyl Peroxide and Sulfur in the Regression in the Short Time (24 Hours) of Moderate Acne Vulgaris Grade II (Pimples)","status":"UNKNOWN","sponsor":"Zurita Laboratorio Farmaceutico Ltda.","startDate":"2011-01","conditions":"Treatment of Acne Vulgaris Grade II in a Short Period of Time.","enrollment":62},{"nctId":"NCT00877409","phase":"PHASE3","title":"Safety and Efficacy Study of Acnase Creme in the Treatment of Acne Vulgaris I and II","status":"UNKNOWN","sponsor":"Zurita Laboratorio Farmaceutico Ltda.","startDate":"2009-04","conditions":"Acne Vulgaris","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Benzoyl peroxide and sulfur","genericName":"Benzoyl peroxide and sulfur","companyName":"Zurita Laboratorio Farmaceutico Ltda.","companyId":"zurita-laboratorio-farmaceutico-ltda","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Benzoyl peroxide and sulfur work together to reduce acne by killing acne-causing bacteria, reducing sebum production, and promoting skin cell turnover. Used for Acne vulgaris.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}