{"id":"benzoyl-peroxide-5-and-sulphur-2","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation and erythema"},{"rate":null,"effect":"Dryness and peeling"},{"rate":null,"effect":"Contact dermatitis"},{"rate":null,"effect":"Photosensitivity"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Benzoyl peroxide generates reactive oxygen species that kill acne-causing bacteria (particularly Cutibacterium acnes) and promote skin cell turnover. Sulfur enhances this effect through its own antimicrobial properties and ability to break down keratin, helping to unclog pores and reduce comedone formation. Together, these agents work synergistically to reduce bacterial colonization and normalize skin shedding.","oneSentence":"Benzoyl peroxide acts as an antimicrobial and keratolytic agent, while sulfur provides additional antimicrobial and keratolytic properties to treat acne and related skin conditions.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:04:05.238Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris"},{"name":"Seborrheic dermatitis"},{"name":"Rosacea"}]},"trialDetails":[{"nctId":"NCT00964366","phase":"PHASE4","title":"Study to Determine and Compare the Tolerance and Irritation Potential of Topical Acne Medications","status":"COMPLETED","sponsor":"Stiefel, a GSK Company","startDate":"2009-07","conditions":"Acne Vulgaris","enrollment":53},{"nctId":"NCT01313728","phase":"PHASE4","title":"A Study That Evaluates the Decrease in Irritation When Using Additional Acne Treatment Products","status":"COMPLETED","sponsor":"Bausch Health Americas, Inc.","startDate":"2010-12","conditions":"Acne Vulgaris","enrollment":26},{"nctId":"NCT01260571","phase":"PHASE4","title":"Clinical Study to Evaluate the Efficacy of Topical Medications Containing Benzoyl Peroxide and Sulfur in the Regression in the Short Time (24 Hours) of Moderate Acne Vulgaris Grade II (Pimples)","status":"UNKNOWN","sponsor":"Zurita Laboratorio Farmaceutico Ltda.","startDate":"2011-01","conditions":"Treatment of Acne Vulgaris Grade II in a Short Period of Time.","enrollment":62},{"nctId":"NCT00877409","phase":"PHASE3","title":"Safety and Efficacy Study of Acnase Creme in the Treatment of Acne Vulgaris I and II","status":"UNKNOWN","sponsor":"Zurita Laboratorio Farmaceutico Ltda.","startDate":"2009-04","conditions":"Acne Vulgaris","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":12,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Acnase"],"phase":"phase_3","status":"active","brandName":"Benzoyl Peroxide 5% and Sulphur 2%","genericName":"Benzoyl Peroxide 5% and Sulphur 2%","companyName":"Zurita Laboratorio Farmaceutico Ltda.","companyId":"zurita-laboratorio-farmaceutico-ltda","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Benzoyl peroxide acts as an antimicrobial and keratolytic agent, while sulfur provides additional antimicrobial and keratolytic properties to treat acne and related skin conditions. Used for Acne vulgaris, Seborrheic dermatitis, Rosacea.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}