{"id":"benzoyl-peroxide-4-topical-cream","safety":{"commonSideEffects":[{"rate":"10–20","effect":"Skin irritation and erythema"},{"rate":"5–15","effect":"Dryness and peeling"},{"rate":"1–5","effect":"Contact dermatitis"},{"rate":null,"effect":"Bleaching of hair or fabrics"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Benzoyl peroxide is a potent oxidizing agent that penetrates the skin and decomposes to produce benzoic acid and oxygen radicals, which are bactericidal against Cutibacterium acnes (formerly Propionibacterium acnes). It also has keratolytic properties that help shed dead skin cells and reduce comedone formation. The 4% concentration provides moderate efficacy with generally good tolerability for topical acne treatment.","oneSentence":"Benzoyl peroxide kills acne-causing bacteria and promotes skin cell turnover by generating reactive oxygen species.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:04:05.074Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acne vulgaris (mild to moderate)"},{"name":"Acne rosacea (adjunctive)"}]},"trialDetails":[{"nctId":"NCT07044024","phase":"","title":"An Observational Clinical Study to Evaluate the Efficacy of the CeraVe Skin Care Line","status":"NOT_YET_RECRUITING","sponsor":"ChinaNorm","startDate":"2025-06-27","conditions":"Acne","enrollment":240},{"nctId":"NCT06925386","phase":"PHASE2","title":"The Relationship Between Microbioma Balance and Acne Vulgaris as a New Acne Treatment","status":"NOT_YET_RECRUITING","sponsor":"Universitas Padjadjaran","startDate":"2025-05-01","conditions":"Acne Vulgaris","enrollment":64},{"nctId":"NCT05675501","phase":"PHASE1","title":"Evaluation of Topical Encapsulated Benzoyl Peroxide on the Skin Microbiome and Skin Biophysical Properties","status":"COMPLETED","sponsor":"Sol-Gel Technologies, Ltd.","startDate":"2020-06-10","conditions":"Papulopustular Rosacea","enrollment":31},{"nctId":"NCT05629468","phase":"PHASE3","title":"Comparing Efficacy of Azithromycin and Probiotics for Treatment of Acne Vulgaris","status":"COMPLETED","sponsor":"Pak Emirates Military Hospital","startDate":"2021-10-15","conditions":"Acne Vulgaris","enrollment":75},{"nctId":"NCT04216160","phase":"NA","title":"Skin Acceptance and Efficacy Assessment of a Topical Product in Acne Treatment When Compared to a Placebo.","status":"COMPLETED","sponsor":"YUN NV","startDate":"2019-05-05","conditions":"Acne Vulgaris","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["\"Benoxyl\" by \"Glitz pharma\""],"phase":"phase_3","status":"active","brandName":"Benzoyl Peroxide 4 % Topical Cream","genericName":"Benzoyl Peroxide 4 % Topical Cream","companyName":"Pak Emirates Military Hospital","companyId":"pak-emirates-military-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Benzoyl peroxide kills acne-causing bacteria and promotes skin cell turnover by generating reactive oxygen species. Used for Acne vulgaris (mild to moderate), Acne rosacea (adjunctive).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}