{"id":"benzoyl-peroxide","rwe":[{"pmid":"41891716","year":"2026","title":"Benzoyl Peroxide Wash Is Efficacious in Reducing Cutibacterium acnes Surgical Site Infections After Posterior Spine Surgeries.","finding":"","journal":"Neurosurgery","studyType":"Clinical Study"},{"pmid":"41891349","year":"2026","title":"The efficacy of a bioactive moisturizer in mitigating side effects of acne therapies: a randomized, investigator-blind, split-face trial.","finding":"","journal":"Dermatology reports","studyType":"Clinical Study"},{"pmid":"41853869","year":"2026","title":"Lactobacillus-Based Microbiome Therapy for Acne Vulgaris: A GRADE Systematic Review and Meta-Analysis of Randomized Controlled Trials.","finding":"","journal":"Journal of cosmetic dermatology","studyType":"Clinical Study"},{"pmid":"41847993","year":"2026","title":"Update of the EuroGuiDerm evidence-based guideline for the treatment of acne-Short version.","finding":"","journal":"Journal of the European Academy of Dermatology and Venereology : JEADV","studyType":"Clinical Study"},{"pmid":"41825817","year":"2026","title":"Initiator-particle synergy enables microrough, osteoconductive polymethyl methacrylate bone cement.","finding":"","journal":"Acta biomaterialia","studyType":"Clinical Study"}],"_fda":{"id":"2e310885-eff7-4db0-bf6e-5c2d211de3b0","set_id":"00fb1ee5-6076-4980-8507-9e58a96e6a6b","openfda":{"unii":["W9WZN9A0GM"],"route":["TOPICAL"],"rxcui":["142034"],"spl_id":["2e310885-eff7-4db0-bf6e-5c2d211de3b0"],"brand_name":["Dr. Zenovia Acne Cleanser"],"spl_set_id":["00fb1ee5-6076-4980-8507-9e58a96e6a6b"],"package_ndc":["51326-803-01","51326-803-02"],"product_ndc":["51326-803"],"generic_name":["BENZOYL PEROXIDE"],"product_type":["HUMAN OTC DRUG"],"substance_name":["BENZOYL PEROXIDE"],"manufacturer_name":["Topiderm, Inc."],"application_number":["M006"],"is_original_packager":[true]},"purpose":["Purpose Acne Treatment"],"version":"2","warnings":["Warnings For external use only When using this product Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time. Avoid contact with eyes. If contact occurs, flush thoroughly with water. Keep out of reach of children. If product is swallowed, get medical help or contact a Poison Control Center right away."],"questions":["Questions? Call (800) 445-2595 or visit drzenovia.com"],"when_using":["When using this product Skin irritation and dryness is more likely to occur if you use another topical acne medication at the same time. If irritation occurs, only use one topical acne medication at a time. Avoid contact with eyes. If contact occurs, flush thoroughly with water."],"effective_time":"20240611","active_ingredient":["Active Ingredient Benzoyl Peroxide 10.0%"],"inactive_ingredient":["Inactive Ingredients Aloe Barbadensis Leaf Extract, Bakuchiol, Camellia Sinensis (Green Tea) Leaf Polyphenols, Carbomer, Cucumis Sativus (Cucumber) Fruit Extract, Disodium EDTA, Fragrance, Genistein, Glycerin, Maltodextrin, Phenoxyethanol, Punica Granatum Sterols, Purified Water, Resveratrol, Sodium Benzoate, Sodium C14-16 Olefin Sulfonate, Stearic Acid USP, Tocopheryl Acetate."],"indications_and_usage":["Uses For the treatment and management of acne Penetrates pores to eliminate most acne and blemishes Helps prevent development of new acne blemishes and blackheads"],"spl_unclassified_section":["Drug Facts","REG-ulate360 Active Complex™ Resveratrol, Bakuchiol, Genistein, Camellia Sinensis (Green Tea) Polyphenols, Aloe Barbadensis Leaf Juice, Cucumis Sativus (Cucumber) Fruit Extract.","Distributed by Dr. Zenovia Skincare Babylon, NY 11704"],"dosage_and_administration":["Directions Pump a small amount of cleanser into dampened hands, and gently massage over face and neck using a circular motion. 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PRINCIPAL DISPLAY PANEL - 120 mL Bottle Carton"]},"tags":[{"label":"benzoyl peroxide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"D10AE01","category":"atc"},{"label":"Topical","category":"route"},{"label":"Aerosol","category":"form"},{"label":"Cloth","category":"form"},{"label":"Cream","category":"form"},{"label":"LOE Approaching","category":"status"},{"label":"Acne vulgaris","category":"indication"},{"label":"Atopic dermatitis","category":"indication"},{"label":"Contact dermatitis","category":"indication"},{"label":"Eruption of skin","category":"indication"},{"label":"Granuloma annulare","category":"indication"},{"label":"Pruritus ani","category":"indication"},{"label":"Mayne Pharma","category":"company"},{"label":"Approved 1980s","category":"decade"},{"label":"Dermatologic Agents","category":"pharmacology"}],"phase":"marketed","safety":{"boxedWarnings":[],"safetySignals":[{"date":"","signal":"DRUG INEFFECTIVE","source":"FDA FAERS","actionTaken":"2154 reports"},{"date":"","signal":"DRY SKIN","source":"FDA FAERS","actionTaken":"1750 reports"},{"date":"","signal":"ACNE","source":"FDA FAERS","actionTaken":"1665 reports"},{"date":"","signal":"ERYTHEMA","source":"FDA FAERS","actionTaken":"1482 reports"},{"date":"","signal":"SKIN BURNING SENSATION","source":"FDA FAERS","actionTaken":"1211 reports"},{"date":"","signal":"SKIN IRRITATION","source":"FDA FAERS","actionTaken":"974 reports"},{"date":"","signal":"SKIN EXFOLIATION","source":"FDA FAERS","actionTaken":"714 reports"},{"date":"","signal":"PRURITUS","source":"FDA FAERS","actionTaken":"676 reports"},{"date":"","signal":"INAPPROPRIATE SCHEDULE OF PRODUCT ADMINISTRATION","source":"FDA FAERS","actionTaken":"669 reports"},{"date":"","signal":"RASH","source":"FDA FAERS","actionTaken":"587 reports"}],"commonSideEffects":[{"effect":"Dryness","drugRate":"","severity":"common","organSystem":""},{"effect":"Urticarial reaction","drugRate":"","severity":"common","organSystem":""},{"effect":"Skin irritation","drugRate":"","severity":"common","organSystem":""},{"effect":"Peeling","drugRate":"","severity":"common","organSystem":""},{"effect":"Itching","drugRate":"","severity":"common","organSystem":""},{"effect":"Burning sensation","drugRate":"","severity":"common","organSystem":""},{"effect":"Erythema","drugRate":"","severity":"common","organSystem":""},{"effect":"Inflammation of the face","drugRate":"","severity":"common","organSystem":""},{"effect":"Eye inflammation","drugRate":"","severity":"common","organSystem":""},{"effect":"Nasal inflammation","drugRate":"","severity":"common","organSystem":""},{"effect":"Eye irritation","drugRate":"","severity":"common","organSystem":""},{"effect":"Skin discoloration","drugRate":"","severity":"common","organSystem":""},{"effect":"Oiliness","drugRate":"","severity":"common","organSystem":""},{"effect":"Skin tenderness","drugRate":"","severity":"common","organSystem":""}],"contraindications":["Adrenal cortical hypofunction","Atrophoderma","Blister","Condyloma acuminatum","Crohn's disease","Denuded skin","Diabetes mellitus","Erythroderma","Infection of skin AND/OR subcutaneous tissue","Inflammatory dermatosis","Kidney disease","Peripheral vascular disease","Photosensitivity","Pseudomembranous enterocolitis","Skin irritation","Telangiectasia disorder","Ulcerative colitis"],"specialPopulations":{"Pregnancy":"There are no well-controlled trials in pregnant women treated with adapalene and benzoyl peroxide gel. 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