{"id":"benzokain-sprey","safety":{"commonSideEffects":[{"rate":null,"effect":"Localized irritation or burning at application site"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Methemoglobinemia (rare, with excessive use)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Benzocaine works by inhibiting sodium influx through voltage-gated sodium channels in sensory nerve fibers, thereby preventing depolarization and blocking the generation and conduction of action potentials. This results in local anesthesia of the area where the spray is applied. As a topical spray formulation, it provides rapid onset of anesthesia at the site of application.","oneSentence":"Benzocaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:03:57.082Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical anesthesia for minor pain and discomfort (spray formulation)"}]},"trialDetails":[{"nctId":"NCT04859738","phase":"PHASE3","title":"The Effect of Lidocaine and Benzocaine on Pain and Injection Satisfaction in Peripheral Intravenous Catheter Application","status":"COMPLETED","sponsor":"TC Erciyes University","startDate":"2020-03-04","conditions":"Peripheral Intravenous Catheterization Application","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Benzokain Sprey","genericName":"Benzokain Sprey","companyName":"TC Erciyes University","companyId":"tc-erciyes-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Benzocaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission. Used for Topical anesthesia for minor pain and discomfort (spray formulation).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}