{"id":"benzoctamine","rwe":[{"pmid":"26742028","year":"2016","title":"Synthesis of Chlorinated Tetracyclic Compounds and Testing for Their Potential Antidepressant Effect in Mice.","finding":"","journal":"Molecules (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"10892587","year":"2000","title":"Determination of doxepin and desmethyldoxepin in human plasma using liquid chromatography-tandem mass spectrometry.","finding":"","journal":"Journal of chromatography. B, Biomedical sciences and applications","studyType":"Clinical Study"},{"pmid":"3970918","year":"1985","title":"In vitro inhibition of rat small intestinal absorption by lipophilic organic cations.","finding":"","journal":"Biochimica et biophysica acta","studyType":"Clinical Study"},{"pmid":"3006704","year":"1985","title":"[Behavior of the second messenger cAMP in status asthmaticus before and following administration of theophylline-ethylenediamine].","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"6738305","year":"1984","title":"5HT2 receptors in the rat portal vein: desensitization following cumulative serotonin addition.","finding":"","journal":"Life sciences","studyType":"Clinical Study"}],"tags":[{"label":"benzoctamine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"N05BD01","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"_fixedAt":"2026-03-30T16:37:10.318224","allNames":["benzoctamine","benzoctamine hydrochloride","benzoctamine HCl"],"offLabel":[],"synonyms":["benzoctamine","benzoctamine hydrochloride","benzoctamine HCl"],"timeline":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"benzoctamine","explanation":"Imagine your brain is like a busy city with many thoughts and worries racing around. Benzoctamine helps calm down this activity by influencing the brain's chemistry, making it easier to relax and feel less anxious.","oneSentence":"Benzoctamine works by interacting with the central nervous system to produce a sedative and anxiolytic effect.","technicalDetail":"Benzoctamine is believed to exert its effects through interaction with the GABA receptor, a key component of the central nervous system's inhibitory neurotransmission pathways."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/324","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BENZOCTAMINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:59:01.242407","biosimilars":[],"competitors":[],"genericName":"benzoctamine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"_fixedFields":["pubmed(61)"],"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"734MM7Y191","CHEBI":"CHEBI:135017","INN_ID":"2465","UMLSCUI":"C0053217","ChEMBL_ID":"CHEMBL2110603","KEGG_DRUG":"D03089","DRUGBANK_ID":"DB09021","PUBCHEM_CID":"28425","SECONDARY_CAS_RN":"10085-81-1","MESH_SUPPLEMENTAL_RECORD_UI":"C100247"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":61,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"N05BD01","allCodes":["N05BD01"]},"biosimilarFilings":[],"recentPublications":[{"date":"2016 Jan 5","pmid":"26742028","title":"Synthesis of Chlorinated Tetracyclic Compounds and Testing for Their Potential Antidepressant Effect in Mice.","journal":"Molecules (Basel, Switzerland)"},{"date":"2000 May 26","pmid":"10892587","title":"Determination of doxepin and desmethyldoxepin in human plasma using liquid chromatography-tandem mass spectrometry.","journal":"Journal of chromatography. B, Biomedical sciences and applications"},{"date":"1985 Feb 28","pmid":"3970918","title":"In vitro inhibition of rat small intestinal absorption by lipophilic organic cations.","journal":"Biochimica et biophysica acta"},{"date":"1985","pmid":"3006704","title":"[Behavior of the second messenger cAMP in status asthmaticus before and following administration of theophylline-ethylenediamine].","journal":"Arzneimittel-Forschung"},{"date":"1984 Jul 2","pmid":"6738305","title":"5HT2 receptors in the rat portal vein: desensitization following cumulative serotonin addition.","journal":"Life sciences"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"BENZOCTAMINE","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Benzoctamine is a small molecule drug in the benzoctamine class, originally developed by an unknown entity and currently owned by an unknown entity. Its target and exact mechanism of action are unknown, but it is used to treat various conditions. The commercial status of benzoctamine is unclear, and it may be patented or available as a generic medication. Key safety considerations are not well-documented. Further research is needed to fully understand its pharmacological properties and clinical applications.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}