{"id":"benzathine-phenoxymethylpenicillin","rwe":[],"tags":[{"label":"benzathine phenoxymethylpenicillin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"J01CE10","category":"atc"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"_fixedAt":"2026-03-30T16:37:03.788411","allNames":["benzathine phenoxymethylpenicillin"],"offLabel":[],"synonyms":["benzathine phenoxymethylpenicillin"],"timeline":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"benzathine phenoxymethylpenicillin","explanation":"Imagine your body's cells are like buildings, and the bacteria are like construction workers. Benzathine phenoxymethylpenicillin stops the construction workers from building new walls, which eventually causes the building to collapse and die. This is how it kills bacteria and treats infections.","oneSentence":"Benzathine phenoxymethylpenicillin works by inhibiting bacterial cell wall synthesis, ultimately leading to bacterial cell death.","technicalDetail":"Benzathine phenoxymethylpenicillin exerts its antibacterial effect by inhibiting the transpeptidase enzyme, which is essential for bacterial cell wall synthesis. This leads to the accumulation of peptidoglycan precursors, causing the bacterial cell wall to weaken and eventually lyse."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4440","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=benzathine%20phenoxymethylpenicillin","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=benzathine phenoxymethylpenicillin","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:58:51.488589","biosimilars":[],"competitors":[{"drugName":"benzylpenicillin","drugSlug":"benzylpenicillin","fdaApproval":"1947-02-06","relationship":"same-class"},{"drugName":"phenoxymethylpenicillin","drugSlug":"phenoxymethylpenicillin","fdaApproval":"1958-01-13","relationship":"same-class"},{"drugName":"benzathine benzylpenicillin","drugSlug":"benzathine-benzylpenicillin","fdaApproval":"1952-06-27","relationship":"same-class"},{"drugName":"procaine benzylpenicillin","drugSlug":"procaine-benzylpenicillin","fdaApproval":"1948-04-26","relationship":"same-class"}],"genericName":"benzathine phenoxymethylpenicillin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"_fixedFields":["pubmed(2)"],"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"benzylpenicillin","brandName":"benzylpenicillin","genericName":"benzylpenicillin","approvalYear":"1947","relationship":"same-class"},{"drugId":"phenoxymethylpenicillin","brandName":"phenoxymethylpenicillin","genericName":"phenoxymethylpenicillin","approvalYear":"1958","relationship":"same-class"},{"drugId":"benzathine-benzylpenicillin","brandName":"benzathine benzylpenicillin","genericName":"benzathine benzylpenicillin","approvalYear":"1952","relationship":"same-class"},{"drugId":"procaine-benzylpenicillin","brandName":"procaine benzylpenicillin","genericName":"procaine benzylpenicillin","approvalYear":"1948","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT05693545","phase":"PHASE2","title":"GOALIE: Intramuscular vs. Enteral Penicillin Prophylaxis to Prevent Progression of Latent RHD Trial","status":"ACTIVE_NOT_RECRUITING","sponsor":"Children's Hospital Medical Center, Cincinnati","startDate":"2023-09-01","conditions":["Rheumatic Heart Disease"],"enrollment":1004,"completionDate":"2027-09-30"},{"nctId":"NCT02099240","phase":"EARLY_PHASE1","title":"Patients Response to Early Switch To Oral:Osteomyelitis Study","status":"TERMINATED","sponsor":"Julio Ramirez","startDate":"2014-03-06","conditions":["Osteomyelitis"],"enrollment":11,"completionDate":"2018-11-07"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"003470","CHEBI":"CHEBI:31973","RXNORM":"18926","UMLSCUI":"C0053155","ChEMBL_ID":"CHEMBL1396177","PUBCHEM_CID":"64725"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":2,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"J01CE10","allCodes":["J01CE10"]},"biosimilarFilings":[],"recentPublications":[{"date":"2024","pmid":"38431823","title":"Relation of Streptococcus Pyogenes tonsillitis isolate to antimicrobial agents and its infection treatment.","journal":"Wiadomosci lekarskie (Warsaw, Poland : 1960)"},{"date":"1957 Jun 22","pmid":"13436818","title":"Absorption of free acid, potassium, and benzathine phenoxymethylpenicillin after oral administration.","journal":"British medical journal"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"benzathine phenoxymethylpenicillin","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Benzathine phenoxymethylpenicillin is a long-acting form of penicillin, a type of antibiotic. It is a small molecule drug that belongs to the benzathine phenoxymethylpenicillin class. The original developer is unknown, and its current owner is also unknown. It is used to treat bacterial infections, but its exact indications and commercial status are unclear. As a long-acting penicillin, it is designed to provide sustained antibiotic activity over an extended period.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}