{"id":"benzalkonium-chloride-spermicide-cream","safety":{"commonSideEffects":[{"rate":null,"effect":"Vaginal irritation"},{"rate":null,"effect":"Local allergic reaction"},{"rate":null,"effect":"Genital discomfort"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a quaternary ammonium compound, benzalkonium chloride acts as a surfactant that damages the lipid bilayer of sperm cell membranes, leading to loss of motility and cell death. This prevents sperm from reaching and fertilizing the ovum. The cream formulation allows for topical vaginal application to create a local contraceptive barrier.","oneSentence":"Benzalkonium chloride is a cationic surfactant that disrupts sperm cell membranes, immobilizing and killing sperm to prevent fertilization.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:42:59.720Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Contraception / prevention of pregnancy"}]},"trialDetails":[{"nctId":"NCT03102450","phase":"PHASE4","title":"Contraceptive Efficacy, Tolerance and Acceptability of a Benzalkonium Chloride Spermicide Cream In Women Aged Over 40 Years of Age","status":"COMPLETED","sponsor":"Laboratoire Innotech International","startDate":"2017-12-26","conditions":"Contraception","enrollment":151}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Pharmatex 1,2% vaginal cream"],"phase":"marketed","status":"active","brandName":"Benzalkonium Chloride Spermicide Cream","genericName":"Benzalkonium Chloride Spermicide Cream","companyName":"Laboratoire Innotech International","companyId":"laboratoire-innotech-international","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Benzalkonium chloride is a cationic surfactant that disrupts sperm cell membranes, immobilizing and killing sperm to prevent fertilization. Used for Contraception / prevention of pregnancy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}