{"id":"benzalkonium-chloride-benzocaine-topical","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or sensitization"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Burning or stinging at application site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Benzalkonium chloride is a quaternary ammonium compound that disrupts bacterial cell membranes, providing antiseptic/antimicrobial activity. Benzocaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing pain signal transmission. Together, this combination provides both antimicrobial protection and topical pain relief.","oneSentence":"Benzalkonium chloride acts as an antimicrobial agent while benzocaine provides local anesthetic effects through sodium channel blockade.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:28:19.939Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Minor cuts, wounds, and abrasions requiring antiseptic and anesthetic treatment"},{"name":"Topical pain relief with antimicrobial protection"}]},"trialDetails":[{"nctId":"NCT05255016","phase":"PHASE2, PHASE3","title":"Safety and Effectiveness of the PXL Platinum 330 System With Riboflavin Solution for Refractory Corneal Ulcers","status":"UNKNOWN","sponsor":"Peschke GmbH","startDate":"2022-03-14","conditions":"Keratitis, Corneal Ulcer","enrollment":488},{"nctId":"NCT03323528","phase":"PHASE4","title":"Safety and Efficacy of a Sore Throat Lozenge DORITHRICIN in Patients With Acute Pharyngitis","status":"COMPLETED","sponsor":"Medice Arzneimittel Pütter GmbH & Co KG","startDate":"2017-02-01","conditions":"Pharyngitis","enrollment":321}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["triple combination"],"phase":"marketed","status":"active","brandName":"Benzalkonium Chloride-Benzocaine Topical","genericName":"Benzalkonium Chloride-Benzocaine Topical","companyName":"Medice Arzneimittel Pütter GmbH & Co KG","companyId":"medice-arzneimittel-p-tter-gmbh-co-kg","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Benzalkonium chloride acts as an antimicrobial agent while benzocaine provides local anesthetic effects through sodium channel blockade. Used for Minor cuts, wounds, and abrasions requiring antiseptic and anesthetic treatment, Topical pain relief with antimicrobial protection.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}