{"id":"benproperine","rwe":[],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"R05DB02","category":"atc"},{"label":"Active","category":"status"},{"label":"Cough","category":"indication"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=BENPROPERINE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-19T23:46:48.965058+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-19T23:47:04.944953+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-19T23:46:55.057633+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BENPROPERINE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-19T23:46:55.383934+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL2105910/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-19T23:46:56.165532+00:00"}},"allNames":"cofrel","offLabel":[],"synonyms":["cofrel","benproperine","benproperine phosphate","flaveric","benproperine dihydrogen phosphate","benproperine embonate","benproperine pamoate","tussafug"],"timeline":[],"aiSummary":"BENPROPERINE (Cofrel) is a marketed cough medication with a key composition patent expiring in 2028. Its key strength lies in its specific molecular target interaction, which differentiates it from off-patent competitors like benzonatate, pentoxyverine, and clofedanol. The primary risk is the potential increase in competition from generics once the patent expires in 2028.","brandName":"Cofrel","ecosystem":[{"indication":"Cough","otherDrugs":[{"name":"ammonium chloride","slug":"ammonium-chloride","company":"B Braun"},{"name":"benzocaine","slug":"benzocaine","company":""},{"name":"benzonatate","slug":"benzonatate","company":"Pfizer"},{"name":"bromazine","slug":"bromazine","company":"Forest Labs"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","explanation":"","oneSentence":"","technicalDetail":"The exact mechanism of action of Cofrel is not specified, but it is believed to involve interaction with a specific molecular target to produce its therapeutic effect."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/5236","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BENPROPERINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:58:36.715340","_validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-19T23:47:04.945087+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"benzonatate","drugSlug":"benzonatate","fdaApproval":"1958-02-10","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"pentoxyverine","drugSlug":"pentoxyverine","fdaApproval":"","relationship":"same-class"},{"drugName":"clofedanol","drugSlug":"clofedanol","fdaApproval":"","relationship":"same-class"}],"genericName":"benproperine","indications":{"approved":[{"name":"Cough","source":"DrugCentral","snomedId":49727002,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"benzonatate","brandName":"benzonatate","genericName":"benzonatate","approvalYear":"1958","relationship":"same-class"},{"drugId":"pentoxyverine","brandName":"pentoxyverine","genericName":"pentoxyverine","approvalYear":"","relationship":"same-class"},{"drugId":"clofedanol","brandName":"clofedanol","genericName":"clofedanol","approvalYear":"","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"006729","UNII":"3AA6IZ48YK","CHEBI":"CHEBI:37560","INN_ID":"3118","RXNORM":"236749","UMLSCUI":"C0772056","chemblId":"CHEMBL2105910","ChEMBL_ID":"CHEMBL2105910","KEGG_DRUG":"D01427","DRUGBANK_ID":"DB13309","PUBCHEM_CID":"2326","SNOMEDCT_US":"703110003","SECONDARY_CAS_RN":"19428-14-9","MESH_SUPPLEMENTAL_RECORD_UI":"C477447"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":22,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"R05DB02","allCodes":["R05DB02"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":1,"lastValidatedAt":"2026-04-19T23:47:04.945087+00:00","fieldsConflicting":1,"overallConfidence":0.8},"verificationStatus":"enriching","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":false,"score":1}}