{"id":"bencyclane","rwe":[{"pmid":"29302962","year":"2018","title":"A Selective and Functional Group-Tolerant Ruthenium-Catalyzed Olefin Metathesis/Transfer Hydrogenation Tandem Sequence Using Formic Acid as Hydrogen Source.","finding":"","journal":"The Journal of organic chemistry","studyType":"Clinical Study"},{"pmid":"25283255","year":"2014","title":"Treatment for calcium channel blocker poisoning: a systematic review.","finding":"","journal":"Clinical toxicology (Philadelphia, Pa.)","studyType":"Clinical Study"},{"pmid":"23910898","year":"2014","title":"Reconstruction of isolated mandibular bone defects with non-vascularized corticocancellous bone autograft and graft viability.","finding":"","journal":"Auris, nasus, larynx","studyType":"Clinical Study"},{"pmid":"23285704","year":"2012","title":"Examination of antimicrobial activity of selected non-antibiotic medicinal preparations.","finding":"","journal":"Acta poloniae pharmaceutica","studyType":"Clinical Study"},{"pmid":"18522569","year":"2008","title":"Effect of bencyclane fumarate on intestinal ischaemia reperfusion injury.","finding":"","journal":"ANZ journal of surgery","studyType":"Clinical Study"}],"tags":[{"label":"bencyclane","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C04AX11","category":"atc"},{"label":"Active","category":"status"},{"label":"Cerebrovascular disease","category":"indication"},{"label":"Calcium Channel Blockers","category":"pharmacology"},{"label":"Calcium-Regulating Hormones and Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Membrane Transport Modulators","category":"pharmacology"},{"label":"Vasodilator Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"benzcyclan","offLabel":[],"synonyms":["bencyclane","benzcyclan","benzcyclane","bencyclane fumarate"],"timeline":[],"brandName":"Benzcyclan","ecosystem":[{"indication":"Cerebrovascular disease","otherDrugs":[{"name":"isoxsuprine","slug":"isoxsuprine","company":""},{"name":"tolazoline","slug":"tolazoline","company":"Novartis"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"bencyclane","explanation":"Imagine your brain is like a garden that needs water to grow. Bencyclane helps to open up the 'pipes' that bring water to the garden, making it easier for the brain to get the blood it needs. This can help to prevent damage to the brain and improve symptoms of cerebrovascular disease.","oneSentence":"Bencyclane works by relaxing blood vessels and improving blood flow to the brain.","technicalDetail":"Bencyclane is a vasodilator that acts on the smooth muscle of blood vessels to increase blood flow and reduce vascular resistance, thereby improving cerebral perfusion and reducing the risk of ischemic events."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/301","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BENCYCLANE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:55:40.965594","biosimilars":[],"competitors":[{"drugName":"phenoxybenzamine","drugSlug":"phenoxybenzamine","fdaApproval":"1953-01-26","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"bencyclane","indications":{"approved":[{"name":"Cerebrovascular disease","source":"DrugCentral","snomedId":62914000,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"phenoxybenzamine","brandName":"phenoxybenzamine","genericName":"phenoxybenzamine","approvalYear":"1953","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000166387","NDDF":"007134","UNII":"6I97Z6S135","CHEBI":"CHEBI:135205","INN_ID":"2111","RXNORM":"1367","UMLSCUI":"C0004969","ChEMBL_ID":"CHEMBL2110767","KEGG_DRUG":"D07500","DRUGBANK_ID":"DB13488","PUBCHEM_CID":"2312","SECONDARY_CAS_RN":"14286-84-1","MESH_DESCRIPTOR_UI":"D001537"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","bioavailability":"51%"},"publicationCount":0,"therapeuticAreas":["Hematology"],"atcClassification":{"source":"DrugCentral","atcCode":"C04AX11","allCodes":["C04AX11"]},"biosimilarFilings":[],"recentPublications":[{"date":"2018 Mar 2","pmid":"29302962","title":"A Selective and Functional Group-Tolerant Ruthenium-Catalyzed Olefin Metathesis/Transfer Hydrogenation Tandem Sequence Using Formic Acid as Hydrogen Source.","journal":"The Journal of organic chemistry"},{"date":"2014 Nov","pmid":"25283255","title":"Treatment for calcium channel blocker poisoning: a systematic review.","journal":"Clinical toxicology (Philadelphia, Pa.)"},{"date":"2014 Feb","pmid":"23910898","title":"Reconstruction of isolated mandibular bone defects with non-vascularized corticocancellous bone autograft and graft viability.","journal":"Auris, nasus, larynx"},{"date":"2012 Nov-Dec","pmid":"23285704","title":"Examination of antimicrobial activity of selected non-antibiotic medicinal preparations.","journal":"Acta poloniae pharmaceutica"},{"date":"2008 Jun","pmid":"18522569","title":"Effect of bencyclane fumarate on intestinal ischaemia reperfusion injury.","journal":"ANZ journal of surgery"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Benzcyclan is a small molecule with the synonyms BENCICLANO, BENCYCLANE, and BENCYCLANE.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}