{"id":"benadryl-demand","safety":{"commonSideEffects":[{"rate":"25-50","effect":"Drowsiness/sedation"},{"rate":"10-20","effect":"Dry mouth"},{"rate":"5-15","effect":"Dizziness"},{"rate":"5-10","effect":"Anticholinergic effects (urinary retention, constipation)"}]},"_chembl":{"chemblId":"CHEMBL1201245","moleculeType":"Small molecule","molecularWeight":"334.26"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Diphenhydramine competitively antagonizes H1 histamine receptors on various tissues, preventing histamine-mediated effects such as itching, urticaria, and allergic reactions. It also has anticholinergic properties that contribute to its sedating effects. The drug crosses the blood-brain barrier readily, which accounts for its central nervous system effects including drowsiness.","oneSentence":"Benadryl (diphenhydramine) is a first-generation antihistamine that blocks H1 histamine receptors to reduce allergic and inflammatory responses.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:41:12.491Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic reactions and urticaria"},{"name":"Pruritus"},{"name":"Allergic rhinitis"},{"name":"Motion sickness and nausea"},{"name":"Insomnia"}]},"trialDetails":[{"nctId":"NCT01158820","phase":"PHASE4","title":"Alternative Sedation During Bronchoscopy","status":"COMPLETED","sponsor":"University of Pennsylvania","startDate":"2010-06","conditions":"Sedation","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Diphenhydramine Hcl","Aler-Dryl","Banophen","Ben Tann","Bromanate AF"],"phase":"marketed","status":"active","brandName":"Benadryl demand","genericName":"Benadryl demand","companyName":"University of Pennsylvania","companyId":"university-of-pennsylvania","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Benadryl (diphenhydramine) is a first-generation antihistamine that blocks H1 histamine receptors to reduce allergic and inflammatory responses. Used for Allergic reactions and urticaria, Pruritus, Allergic rhinitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}