{"id":"benactyzine","rwe":[{"pmid":"41832974","year":"2026","title":"The Underlying Mechanism of Shanxian Granule in the Treatment of Glioma Based on Network Pharmacological and Bioinformatics Analysis.","finding":"","journal":"Current topics in medicinal chemistry","studyType":"Clinical Study"},{"pmid":"36302937","year":"2022","title":"Synthesis and preliminary biological evaluation of gabactyzine, a benactyzine-GABA mutual prodrug, as an organophosphate antidote.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"},{"pmid":"34083530","year":"2021","title":"Visible-light photoredox-catalyzed umpolung carboxylation of carbonyl compounds with CO(2).","finding":"","journal":"Nature communications","studyType":"Clinical Study"},{"pmid":"31999021","year":"2020","title":"Room Temperature Coupling of Aryldiazoacetates with Boronic Acids Enhanced by Blue Light Irradiation.","finding":"","journal":"Chemistry (Weinheim an der Bergstrasse, Germany)","studyType":"Clinical Study"},{"pmid":"30827238","year":"2019","title":"Some Possibilities to Study New Prophylactics against Nerve Agents.","finding":"","journal":"Mini reviews in medicinal chemistry","studyType":"Clinical Study"}],"tags":[{"label":"benactyzine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Antidepressive Agents","category":"pharmacology"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Cholinergic Agents","category":"pharmacology"},{"label":"Cholinergic Antagonists","category":"pharmacology"},{"label":"Muscarinic Antagonists","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"},{"label":"Parasympatholytics","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Psychotropic Drugs","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"diazil","offLabel":[],"synonyms":["benactyzine","benactyzin","diethylaminoethyl benzilate","diazil","benactyzine hydrochloride","benactyzine HCl"],"timeline":[],"brandName":"Diazil","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"benactyzine","explanation":"Imagine your brain is a busy city with many different streets and intersections. Diazil is like a traffic manager that helps regulate the flow of information between different parts of the city, keeping things running smoothly. By doing so, it can help alleviate symptoms of certain conditions.","oneSentence":"Diazil is thought to work by modulating neurotransmitter activity in the central nervous system.","technicalDetail":"The exact mechanism of action of Diazil is unknown, but it is believed to interact with nicotinic acetylcholine receptors, which play a crucial role in regulating neurotransmitter activity in the central nervous system."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/298","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BENACTYZINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:58:03.064459","biosimilars":[],"competitors":[],"genericName":"benactyzine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000147719","NDDF":"001505","UNII":"595EG71R3F","VUID":"4019626","CHEBI":"CHEBI:94775","VANDF":"4018455","INN_ID":"496","RXNORM":"1361","UMLSCUI":"C0004962","ChEMBL_ID":"CHEMBL70352","KEGG_DRUG":"D07498","DRUGBANK_ID":"DB09023","PUBCHEM_CID":"9330","SNOMEDCT_US":"412215005","SECONDARY_CAS_RN":"57-37-4","MESH_DESCRIPTOR_UI":"D001535"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Mar 6","pmid":"41832974","title":"The Underlying Mechanism of Shanxian Granule in the Treatment of Glioma Based on Network Pharmacological and Bioinformatics Analysis.","journal":"Current topics in medicinal chemistry"},{"date":"2022 Oct 27","pmid":"36302937","title":"Synthesis and preliminary biological evaluation of gabactyzine, a benactyzine-GABA mutual prodrug, as an organophosphate antidote.","journal":"Scientific reports"},{"date":"2021 Jun 3","pmid":"34083530","title":"Visible-light photoredox-catalyzed umpolung carboxylation of carbonyl compounds with CO(2).","journal":"Nature communications"},{"date":"2020 May 4","pmid":"31999021","title":"Room Temperature Coupling of Aryldiazoacetates with Boronic Acids Enhanced by Blue Light Irradiation.","journal":"Chemistry (Weinheim an der Bergstrasse, Germany)"},{"date":"2019","pmid":"30827238","title":"Some Possibilities to Study New Prophylactics against Nerve Agents.","journal":"Mini reviews in medicinal chemistry"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Diazil is a small molecule. Its exact mechanism of action is not specified in the provided information.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}