{"id":"belantamab-mafodotin-lyophilized-powder","safety":{"commonSideEffects":[{"rate":"45%","effect":"Neutropenia"},{"rate":"43%","effect":"Thrombocytopenia"},{"rate":"42%","effect":"Anemia"},{"rate":"34%","effect":"Fatigue"},{"rate":"32%","effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL4298209","moleculeType":"Antibody drug conjugate"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Belantamab mafodotin is a monoclonal antibody-drug conjugate that targets B cell maturation antigen (BCMA) on the surface of multiple myeloma cells.","oneSentence":"Monoclonal antibody targeting BCMA","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:22:39.729Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Multiple myeloma"}]},"trialDetails":[{"nctId":"NCT03525678","phase":"PHASE2","title":"A Study to Investigate the Efficacy and Safety of Two Doses of GSK2857916 in Participants With Multiple Myeloma Who Have Failed Prior Treatment With an Anti-CD38 Antibody","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2018-06-18","conditions":"Multiple Myeloma","enrollment":221},{"nctId":"NCT04398745","phase":"PHASE1","title":"A Study of Belantamab Mafodotin Monotherapy in Multiple Myeloma Participants With Normal and Varying Degree of Impaired Renal Function","status":"ACTIVE_NOT_RECRUITING","sponsor":"GlaxoSmithKline","startDate":"2020-10-09","conditions":"Multiple Myeloma","enrollment":36},{"nctId":"NCT04177823","phase":"PHASE1","title":"A Study of Belantamab Mafodotin to Investigate Safety, Tolerability, Pharmacokinetics, Immunogenicity and Clinical Activity in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2019-12-09","conditions":"Multiple Myeloma","enrollment":6},{"nctId":"NCT05280275","phase":"PHASE1, PHASE2","title":"A Study to Investigate the Safety and Clinical Activity of Belantamab Mafodotin in Combination With Daratumumab, Lenalidomide and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Transplant Ineligible","status":"UNKNOWN","sponsor":"Hellenic Society of Hematology","startDate":"2022-04-13","conditions":"Multiple Myeloma, Neoplasms, Neoplasms, Plasma Cell","enrollment":36},{"nctId":"NCT05573802","phase":"PHASE1, PHASE2","title":"A Study to Investigate Safety and Clinical Activity of Belantamab Mafodotin in Combination With Lenalidomide, Dexamethasone and Nirogacestat in Patients With Transplant Ineligible Newly Diagnosed Multiple Myeloma","status":"RECRUITING","sponsor":"Hellenic Society of Hematology","startDate":"2023-07-14","conditions":"Multiple Myeloma, Neoplasms, Neoplasm, Plasma Cell","enrollment":36},{"nctId":"NCT05581875","phase":"PHASE1, PHASE2","title":"A Study to Investigate the Safety and Clinical Activity of Belantamab Mafodotin in Combination With Daratumumab, Pomalidomide and Dexamethasone in Patients With Relapsed/ Refractory Multiple Myeloma Previously Treated With One Line Therapy Who Are Lenalidomide Refractory","status":"NOT_YET_RECRUITING","sponsor":"Hellenic Society of Hematology","startDate":"2022-10-20","conditions":"Multiple Myeloma, Multiple Myeloma in Relapse, Neoplasms","enrollment":48}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"Belantamab mafodotin lyophilized powder","genericName":"Belantamab mafodotin lyophilized powder","companyName":"GlaxoSmithKline","companyId":"gsk","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Monoclonal antibody targeting BCMA Used for Multiple myeloma.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}