{"id":"befunolol","rwe":[],"tags":[{"label":"befunolol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"S01ED06","category":"atc"},{"label":"Active","category":"status"},{"label":"Ocular hypertension","category":"indication"},{"label":"Open-angle glaucoma","category":"indication"},{"label":"Adrenergic Agents","category":"pharmacology"},{"label":"Adrenergic Agonists","category":"pharmacology"},{"label":"Adrenergic Antagonists","category":"pharmacology"},{"label":"Adrenergic beta-Agonists","category":"pharmacology"},{"label":"Adrenergic beta-Antagonists","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"phase_2","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"bentos","offLabel":[],"synonyms":["bentos","befunolol","befunolol hydrochloride","befunolol HCl"],"timeline":[],"brandName":"Bentos","ecosystem":[{"indication":"Ocular hypertension","otherDrugs":[{"name":"betaxolol","slug":"betaxolol","company":"Alcon"},{"name":"bimatoprost","slug":"bimatoprost","company":""},{"name":"brimonidine","slug":"brimonidine","company":""},{"name":"brinzolamide","slug":"brinzolamide","company":"Alcon Pharms Ltd"}],"globalPrevalence":1280000000},{"indication":"Open-angle glaucoma","otherDrugs":[{"name":"acetazolamide","slug":"acetazolamide","company":"Teva Branded Pharm"},{"name":"apraclonidine","slug":"apraclonidine","company":"Alcon"},{"name":"betaxolol","slug":"betaxolol","company":"Alcon"},{"name":"bimatoprost","slug":"bimatoprost","company":""}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"befunolol","explanation":"Think of the eye like a balloon filled with water. When the balloon gets too full, the pressure inside the balloon increases. Bentos helps to reduce the amount of water in the balloon, which in turn lowers the pressure inside the eye.","oneSentence":"Bentos works by reducing the production of fluid in the eye, thereby lowering intraocular pressure.","technicalDetail":"Befunolol is a non-selective beta-adrenergic receptor blocker that inhibits the production of aqueous humor, thereby reducing intraocular pressure."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/295","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BEFUNOLOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:49:50.264501","biosimilars":[],"competitors":[{"drugName":"timolol","drugSlug":"timolol","fdaApproval":"1978-08-17","genericCount":2,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"betaxolol","drugSlug":"betaxolol","fdaApproval":"1985-08-30","genericCount":6,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"levobunolol","drugSlug":"levobunolol","fdaApproval":"1985-12-19","genericCount":5,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"metipranolol","drugSlug":"metipranolol","fdaApproval":"1989-12-29","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"carteolol","drugSlug":"carteolol","fdaApproval":"1988-12-28","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"befunolol","indications":{"approved":[{"name":"Ocular hypertension","source":"DrugCentral","snomedId":4210003,"regulator":"FDA","usPrevalence":119900000,"globalPrevalence":1280000000,"prevalenceMethod":"curated","prevalenceSource":"WHO, 2023"},{"name":"Open-angle glaucoma","source":"DrugCentral","snomedId":84494001,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"timolol","brandName":"timolol","genericName":"timolol","approvalYear":"1978","relationship":"same-class"},{"drugId":"betaxolol","brandName":"betaxolol","genericName":"betaxolol","approvalYear":"1985","relationship":"same-class"},{"drugId":"levobunolol","brandName":"levobunolol","genericName":"levobunolol","approvalYear":"1985","relationship":"same-class"},{"drugId":"metipranolol","brandName":"metipranolol","genericName":"metipranolol","approvalYear":"1989","relationship":"same-class"},{"drugId":"carteolol","brandName":"carteolol","genericName":"carteolol","approvalYear":"1988","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005239","UNII":"418546MT3A","CHEBI":"CHEBI:135212","INN_ID":"4452","UMLSCUI":"C0053071","ChEMBL_ID":"CHEMBL153984","KEGG_DRUG":"D01512","DRUGBANK_ID":"DB09013","PUBCHEM_CID":"2309","SECONDARY_CAS_RN":"39543-79-8","MESH_SUPPLEMENTAL_RECORD_UI":"C006034"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":103,"therapeuticAreas":["Cardiovascular"],"atcClassification":{"source":"DrugCentral","atcCode":"S01ED06","allCodes":["S01ED06"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bentos (Befunolol) is a small molecule drug in the befunolol class, used to treat ocular hypertension and open-angle glaucoma. Its commercial status is unknown, but it is approved for the mentioned indications. The exact target of Bentos is unknown, but it is believed to work by reducing intraocular pressure. Key safety considerations include unknown half-life and bioavailability. As its commercial status is unknown, it is unclear if it is patented or available as a generic.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}