{"id":"bee-venom","safety":{"commonSideEffects":[{"rate":null,"effect":"Local injection site reactions (pain, swelling, erythema)"},{"rate":null,"effect":"Allergic reactions"},{"rate":null,"effect":"Anaphylaxis (in sensitized individuals)"}]},"_chembl":null,"_dailymed":{"setId":"4d48076e-a83f-fbcc-e063-6294a90ace77","title":"NEATIQUE BEE VENOM SKIN CREAM (SKIN CREAM) CREAM [SHENZHEN ZEALOUS ECOMMERCE TECHNOLOGY CO., LTD]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bee venom's primary active component, apitoxin, contains peptides such as melittin and adolapin that inhibit phospholipase A2, reduce prostaglandin and leukotriene production, and modulate cytokine release. These actions suppress inflammatory responses and may enhance regulatory T cell function, making it potentially useful in autoimmune and inflammatory conditions. The venom also has analgesic properties through direct nociceptor modulation.","oneSentence":"Bee venom contains multiple bioactive peptides and enzymes that modulate immune function and reduce inflammation through activation of anti-inflammatory pathways and immune cell regulation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:41:34.367Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Rheumatoid arthritis"},{"name":"Chronic pain conditions"},{"name":"Inflammatory disorders"}]},"trialDetails":[{"nctId":"NCT03879447","phase":"","title":"Effectiveness and Safety of Korean Medicine for Low Back Pain or Sciatica Due to Lumbar Stenosis/Spondylolisthesis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Jaseng Medical Foundation","startDate":"2019-06-24","conditions":"Lumbar Spinal Stenosis, Lumbar Spondylolisthesis, Low Back Pain","enrollment":110},{"nctId":"NCT03959098","phase":"","title":"Effectiveness and Safety of Korean Medicine Treatment for Cervical Disc Herniation","status":"ACTIVE_NOT_RECRUITING","sponsor":"Jaseng Medical Foundation","startDate":"2019-06-24","conditions":"Neck Pain, Cervical Radiculopathy, Intervertebral Disc Displacement","enrollment":120},{"nctId":"NCT04259359","phase":"","title":"Predominant Sensitizations to Single Bee Venom Allergens as a Risk Factor for Therapy Failure","status":"RECRUITING","sponsor":"Medical University of Graz","startDate":"2019-05-02","conditions":"Bee Venom Allergy","enrollment":266},{"nctId":"NCT06876506","phase":"","title":"Identification of B Regulatory Cells by Flow Cytometry","status":"NOT_YET_RECRUITING","sponsor":"Hull University Teaching Hospitals NHS Trust","startDate":"2026-02-01","conditions":"Pollen Allergy, Venom Allergy","enrollment":80},{"nctId":"NCT07151313","phase":"NA","title":"Efficacy of Bee Venom Phonophoresis in Treating Chronic Sinusitis:","status":"NOT_YET_RECRUITING","sponsor":"Sinai University","startDate":"2025-09-15","conditions":"Chronic Sinusitis, Acute Sinusitis, Rhinosinusitis","enrollment":30},{"nctId":"NCT07151300","phase":"NA","title":"Phonophoresis With Bee Venom: Evaluating Its Efficacy in Managing Pain and Enhancing Mobility in Knee Osteoarthritis Patients","status":"NOT_YET_RECRUITING","sponsor":"Sinai University","startDate":"2025-09-15","conditions":"Knee Osteoarthritis, Osteoarthritis","enrollment":30},{"nctId":"NCT07135609","phase":"NA","title":"Apitoxin Versus Soft Laser for Management of Aphthous Ulceration.","status":"COMPLETED","sponsor":"Tanta University","startDate":"2024-04-30","conditions":"Apitoxin, Bee Venom Therapy, Management","enrollment":60},{"nctId":"NCT06782217","phase":"","title":"Prospective Observational Study to Evaluate the Safety of Immunotherapy as a Treatment for Hymenoptera Venom Allergy","status":"RECRUITING","sponsor":"Inmunotek S.L.","startDate":"2024-09-01","conditions":"Allergy, Insect Venom, Allergy Insect Stinging, Insect Sting Allergy","enrollment":120},{"nctId":"NCT06790368","phase":"","title":"Immunotherapy for the Treatment of Hymenoptera Venom Allergy in Real-life Conditions.","status":"RECRUITING","sponsor":"Inmunotek S.L.","startDate":"2025-01-01","conditions":"Allergy, Insect Venom, Allergy Insect Stinging, Insect Sting Allergy","enrollment":80},{"nctId":"NCT06156046","phase":"","title":"Tolerance in Beekeepers","status":"RECRUITING","sponsor":"University Hospital Plymouth NHS Trust","startDate":"2024-01-22","conditions":"Bee Sting","enrollment":120},{"nctId":"NCT06901102","phase":"PHASE1, PHASE2","title":"Effect of Bee Venom on Chronic Kidney Disease-Mineral Bone Disorders in Hemodialysis Patients: a Randomized Controlled Trial","status":"NOT_YET_RECRUITING","sponsor":"Mansoura University","startDate":"2025-04-10","conditions":"Chronic Kidney Disease, Bee Venom, Hemodialysis","enrollment":60},{"nctId":"NCT06148766","phase":"NA","title":"An Investigation of the Effects of a Royal Jelly and Bee Venom-Derived Skin Cream on Skin Health and Signs of Aging","status":"COMPLETED","sponsor":"Manuka Health","startDate":"2023-11-09","conditions":"Skin Health","enrollment":40},{"nctId":"NCT06148753","phase":"NA","title":"An Investigation of the Effects of a Royal Jelly and Bee Venom-Derived Skin Serum on Skin Health and Signs of Aging","status":"COMPLETED","sponsor":"Manuka Health","startDate":"2023-11-09","conditions":"Skin Health","enrollment":40},{"nctId":"NCT06374563","phase":"NA","title":"Tackling Pressure Ulcer Via Bee Venom Phonophoresis","status":"COMPLETED","sponsor":"Badr University","startDate":"2022-11-09","conditions":"Bee Venom, Pressure Ulcers, Phonophoresis","enrollment":30},{"nctId":"NCT06106230","phase":"NA","title":"Bee Venom Phonophoresis on Mild to Moderate Localized Plaque Psoriasis on Knee Joint","status":"COMPLETED","sponsor":"MTI University","startDate":"2024-01-01","conditions":"Plaque Psoriasis","enrollment":100},{"nctId":"NCT02257723","phase":"","title":"The Effect of Integrated CAM Treatment in Hospitalized Patients","status":"RECRUITING","sponsor":"Jaseng Hospital of Korean Medicine","startDate":"2012-01","conditions":"Low Back Pain, Neck Pain, Knee Pain","enrollment":100000},{"nctId":"NCT05937061","phase":"","title":"Influence of Persistent Food Allergy on Nutritional Status of Children With Food Allergy","status":"COMPLETED","sponsor":"University Medical Centre Ljubljana","startDate":"2019-05-01","conditions":"Food Allergy","enrollment":130},{"nctId":"NCT02841163","phase":"","title":"Disc Resorption in Lumbar and Cervical Disc Herniation Patients Receiving Integrative Korean Medicine Treatment","status":"COMPLETED","sponsor":"Jaseng Medical Foundation","startDate":"2016-04","conditions":"Lumbar Intervertebral Disc Displacement, Cervical Intervertebral Disc Displacement","enrollment":505},{"nctId":"NCT04435678","phase":"NA","title":"Diagnostic Accuracy of the MADx Multi Array Xplorer (MAX 45k) Automated Laboratory System and the MADx Allergy Explorer Version 2 (ALEX²) - IgE Multiplex Test for the Diagnosis of Pre-defined Groups of Specific High-priority Allergens","status":"COMPLETED","sponsor":"MacroArray Diagnostics GmbH","startDate":"2020-07-22","conditions":"Birch Pollen Allergy, Grass Pollen Allergy, House Dust Mite Allergy","enrollment":839},{"nctId":"NCT05286463","phase":"NA","title":"Effect of Ultrasound-enhanced Bee Venom on Selected Post Inguinal Hernioplasty Complications","status":"COMPLETED","sponsor":"Cairo University","startDate":"2021-03-02","conditions":"Complications; C, Intestinal (Internal)","enrollment":66},{"nctId":"NCT05285930","phase":"NA","title":"Effect of Bee Venom Phonophoresis on Healing of Chronic Lower Limb Ulcers","status":"COMPLETED","sponsor":"Cairo University","startDate":"2021-08-01","conditions":"Ulcer, Leg","enrollment":45},{"nctId":"NCT03750591","phase":"","title":"Observational Study on Effectiveness and Safety of Integrative Korean Medicine Treatment for Inpatients With Sciatica Due to Lumbar Intervertebral Disc Herniation","status":"COMPLETED","sponsor":"Jaseng Medical Foundation","startDate":"2018-03-31","conditions":"Sciatica Due to Intervertebral Disc Disorder, Intervertebral Disc Displacement, Sciatica","enrollment":1000},{"nctId":"NCT03571503","phase":"","title":"The Effectiveness of Doin (Conduction Exercise) of the Pelvic Joint for HLD With Radiating Leg Pain","status":"COMPLETED","sponsor":"Jaseng Medical Foundation","startDate":"2018-07-09","conditions":"Intervertebral Disc Displacement, Sciatica, Sciatic Radiculopathy","enrollment":40},{"nctId":"NCT03858556","phase":"","title":"Effect of Chuna Manipulation Therapy on Gait in Patients With Lumbar Disc Herniation","status":"WITHDRAWN","sponsor":"Jaseng Medical Foundation","startDate":"2019-02-27","conditions":"Lumbar Disc Herniation, Gait Analysis, Manual Therapy","enrollment":""},{"nctId":"NCT01791933","phase":"","title":"The Evaluation of the Effectiveness of CAM Treatments for Lumbar and Cervical Spine Pain Patients Due to Spinal Disease","status":"COMPLETED","sponsor":"Jaseng Hospital of Korean Medicine","startDate":"2013-02","conditions":"Lumbar and Cervical Pain","enrollment":111},{"nctId":"NCT02364349","phase":"PHASE1","title":"A Comparative Study on Local Allergic Responses of Bee Venom and Essential Bee Venom Pharmacopuncture","status":"COMPLETED","sponsor":"Jaseng Hospital of Korean Medicine","startDate":"2015-01","conditions":"Healthy Volunteers","enrollment":20},{"nctId":"NCT01701804","phase":"","title":"The Effectiveness of Non-surgical Integrative Package on Failed Back Surgery Syndrome","status":"COMPLETED","sponsor":"Jaseng Hospital of Korean Medicine","startDate":"2011-09","conditions":"Failed Back Surgery Syndrome","enrollment":120},{"nctId":"NCT01989403","phase":"","title":"Alternative and Integrative Therapy for Lumbar Disk Herniation","status":"COMPLETED","sponsor":"Jaseng Hospital of Korean Medicine","startDate":"2006-02","conditions":"Sciatica, Intervertebral Disc Disorder","enrollment":128},{"nctId":"NCT02975011","phase":"","title":"Effectiveness and Safety of Korean Medicine for Lumbar Stenosis Patients With Sciatica","status":"TERMINATED","sponsor":"Jaseng Medical Foundation","startDate":"2017-03-04","conditions":"Lumbar Spinal Stenosis","enrollment":38},{"nctId":"NCT02299739","phase":"","title":"Liver Enzyme Abnormalities and Risk Factors in Taking Herbal Medicine","status":"COMPLETED","sponsor":"Jaseng Hospital of Korean Medicine","startDate":"2005-12","conditions":"Drug-Induced Liver Injury, Musculoskeletal Diseases","enrollment":6894},{"nctId":"NCT03710655","phase":"PHASE3","title":"Evaluate Safety and Efficacy of Apitox Add-on Therapy for Improving Disability and Quality of Life in MS Patients","status":"UNKNOWN","sponsor":"Apimeds, Inc.","startDate":"2019-04","conditions":"Multiple Sclerosis","enrollment":468},{"nctId":"NCT02101632","phase":"NA","title":"Myorelaxant Effect of Bee Venom(BV) Topical Skin Application in Patients With RDC/TMD Ia and Ib","status":"COMPLETED","sponsor":"Medical University of Silesia","startDate":"2014-02","conditions":"Other Disorders of Muscle in Diseases Classified Elsewhere","enrollment":79},{"nctId":"NCT01112722","phase":"PHASE3","title":"Apitox, Honeybee Toxin for Pain and Inflammation of Osteoarthritis","status":"COMPLETED","sponsor":"Apimeds, Inc.","startDate":"2013-12","conditions":"Osteoarthritis of the Knee","enrollment":363},{"nctId":"NCT02968394","phase":"NA","title":"Omalizumab Treatment in Venom Immunotherapy With Systemic Reactions","status":"UNKNOWN","sponsor":"The University Clinic of Pulmonary and Allergic Diseases Golnik","startDate":"2014-03","conditions":"Allergy, Bee Venom, Immunotherapy","enrollment":11},{"nctId":"NCT01922466","phase":"PHASE2","title":"East-West Collaboration Treatment Using Bee Venom Acupuncture and NSAIDs for Chronic Cervicalgia","status":"COMPLETED","sponsor":"Kyunghee University Medical Center","startDate":"2013-07","conditions":"Chronic Non-specific, Uncomplicated Neck Pain","enrollment":60},{"nctId":"NCT01970813","phase":"NA","title":"Efficacy of Acupuncture and Bee Venom Acupuncture on Patients With Idiopathic Parkinson's Disease","status":"COMPLETED","sponsor":"Kyunghee University Medical Center","startDate":"2012-10","conditions":"Idiopathic Parkinson's Disease","enrollment":74},{"nctId":"NCT01341431","phase":"PHASE2","title":"Bee Venom for the Treatment of Parkinson Disease","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2011-03","conditions":"Parkinson Disease","enrollment":50},{"nctId":"NCT00263952","phase":"PHASE3","title":"Efficacy and Safety of a Purified Standardised Bee Venom Preparation","status":"COMPLETED","sponsor":"Allergopharma GmbH & Co. KG","startDate":"2003-03","conditions":"Bee Venom Allergy","enrollment":""},{"nctId":"NCT01491321","phase":"PHASE2","title":"Bee Venom Acupuncture for the Treatment of Chronic Low Back Pain","status":"UNKNOWN","sponsor":"Kyunghee University Medical Center","startDate":"2011-04","conditions":"Chronic Low Back Pain","enrollment":54},{"nctId":"NCT01526031","phase":"PHASE2","title":"Bee Venom Acupuncture for the Treatment of Frozen Shoulder","status":"COMPLETED","sponsor":"Kyunghee University Medical Center","startDate":"2010-01","conditions":"Frozen Shoulder","enrollment":68},{"nctId":"NCT01369238","phase":"NA","title":"East-West Collaborative Medicine Using Bee-Venom Acupuncture on Whiplash-Associated Disorders","status":"UNKNOWN","sponsor":"Korean Pharmacoacupuncture Institute","startDate":"2011-06","conditions":"Whiplash Injuries","enrollment":90},{"nctId":"NCT00949754","phase":"PHASE2","title":"Apitox, Honeybee Venom Treatment for Osteoarthritis Pain and Inflammation","status":"COMPLETED","sponsor":"Apimeds, Inc.","startDate":"2009-10","conditions":"Osteoarthritis of the Knee","enrollment":40},{"nctId":"NCT00947908","phase":"NA","title":"Regulation of Blood Dendritic Cells During Immune Therapy for Hymenoptera Venom Allergy","status":"UNKNOWN","sponsor":"University of Rostock","startDate":"2009-06","conditions":"Hymenoptera Venom Allergy","enrollment":20},{"nctId":"NCT00684476","phase":"PHASE4","title":"Maintenance Bee-Venom Immunotherapy Administered at 6-Month Intervals Does Not Protect Against re-Stings","status":"COMPLETED","sponsor":"Meir Medical Center","startDate":"2004-06","conditions":"Venom Allergy","enrollment":60},{"nctId":"NCT00253942","phase":"PHASE3","title":"Safety and Efficacy Study of Bee Venom to Treat Knee Osteoarthritis","status":"UNKNOWN","sponsor":"Rheumatology Therapeutics Medical Center","startDate":"2005-11","conditions":"Persons With Mild to Moderate Knee Osteoarthritis","enrollment":40}],"_emaApprovals":[],"_faersSignals":[{"count":15,"reaction":"DRUG HYPERSENSITIVITY"},{"count":14,"reaction":"HYPERSENSITIVITY"},{"count":10,"reaction":"ANAPHYLACTIC REACTION"},{"count":8,"reaction":"DIZZINESS"},{"count":8,"reaction":"URTICARIA"},{"count":6,"reaction":"NAUSEA"},{"count":5,"reaction":"DRUG INTERACTION"},{"count":5,"reaction":"DYSPNOEA"},{"count":5,"reaction":"PRURITUS"},{"count":5,"reaction":"VOMITING"}],"_approvalHistory":[],"publicationCount":2844,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["1: Experimental : Bee venom","2: Placebo Comparator : NaCl 0.9%, 1 milliliter s.c."],"phase":"marketed","status":"active","brandName":"bee venom","genericName":"bee venom","companyName":"Assistance Publique - Hôpitaux de Paris","companyId":"assistance-publique-h-pitaux-de-paris","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bee venom contains multiple bioactive peptides and enzymes that modulate immune function and reduce inflammation through activation of anti-inflammatory pathways and immune cell regulation. Used for Rheumatoid arthritis, Chronic pain conditions, Inflammatory disorders.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}