{"id":"bcg-solvent","safety":{"commonSideEffects":[{"rate":null,"effect":"Local injection site reaction (erythema, induration)"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Lymphadenitis"},{"rate":null,"effect":"BCG-itis (disseminated infection, rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"BCG is a weakened strain of Mycobacterium bovis that activates both innate immunity (through pattern recognition receptors) and adaptive immunity (Th1 and Th17 cell responses). It has been used primarily as a tuberculosis vaccine and intravesical immunotherapy for bladder cancer, with emerging evidence for non-specific immune enhancement effects in other infectious diseases.","oneSentence":"BCG (Bacillus Calmette-Guérin) is a live attenuated mycobacterial vaccine that stimulates innate and adaptive immune responses to enhance immunological protection.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:24:43.915Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Tuberculosis prevention"},{"name":"Bladder cancer (intravesical immunotherapy)"},{"name":"Non-specific immune enhancement in infectious disease contexts"}]},"trialDetails":[{"nctId":"NCT05507671","phase":"PHASE3","title":"The Role of BCG Vaccine in the Clinical Evolution of COVID-19 and in the Efficacy of Anti-SARS-CoV-2 Vaccines","status":"ACTIVE_NOT_RECRUITING","sponsor":"Oswaldo Cruz Foundation","startDate":"2021-05-27","conditions":"COVID-19","enrollment":556},{"nctId":"NCT03888924","phase":"PHASE2","title":"Bacille Calmette-Guérin (BCG) Vaccine In Radiologically Isolated Syndrome (RIS)","status":"RECRUITING","sponsor":"S. Andrea Hospital","startDate":"2019-06-17","conditions":"Multiple Sclerosis","enrollment":100},{"nctId":"NCT02953327","phase":"PHASE4","title":"Testing if BCG (Bacille Calmette-Guérin) Vaccination Can Induce Innate Immune Training in Adult People Above 50 Years of Age in Guinea-Bissau","status":"COMPLETED","sponsor":"Bandim Health Project","startDate":"2017-02-01","conditions":"Innate Immunity, Bacille Calmette-Guérin","enrollment":40},{"nctId":"NCT04648800","phase":"PHASE3","title":"Clinical Trial Evaluating the Effect of BCG Vaccination on the Incidence and Severity of SARS-CoV-2 Infections Among Healthcare Professionals During the COVID-19 Pandemic in Poland","status":"UNKNOWN","sponsor":"Hanna Czajka","startDate":"2020-07-07","conditions":"Covid19, BCG Vaccination Reaction, SARS-CoV Infection","enrollment":1000}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":51,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Diluent"],"phase":"marketed","status":"active","brandName":"BCG solvent","genericName":"BCG solvent","companyName":"Bandim Health Project","companyId":"bandim-health-project","modality":"Biologic","firstApprovalDate":"","aiSummary":"BCG (Bacillus Calmette-Guérin) is a live attenuated mycobacterial vaccine that stimulates innate and adaptive immune responses to enhance immunological protection. Used for Tuberculosis prevention, Bladder cancer (intravesical immunotherapy), Non-specific immune enhancement in infectious disease contexts.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}