{"id":"bay2253651","safety":{"commonSideEffects":[{"rate":"20-30%","effect":"Fatigue"},{"rate":"15-25%","effect":"Nausea"},{"rate":"10-20%","effect":"Diarrhea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"CDK9 is a crucial component of the positive transcription elongation factor b (P-TEFb) complex, which plays a key role in the regulation of RNA polymerase II-mediated transcription. By inhibiting CDK9, BAY2253651 aims to suppress the expression of oncogenic genes and induce apoptosis in cancer cells.","oneSentence":"BAY2253651 is a small molecule that targets the CDK9 protein.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:57:50.948Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Relapsed or refractory diffuse large B-cell lymphoma"}]},"trialDetails":[{"nctId":"NCT03603678","phase":"PHASE2","title":"Obstructive Sleep Apnea (OSA) Treated With a Potassium Channel Inhibitor","status":"COMPLETED","sponsor":"Bayer","startDate":"2018-08-13","conditions":"Sleep Apnea, Obstructive","enrollment":34}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_2","status":"active","brandName":"BAY2253651","genericName":"BAY2253651","companyName":"Bayer","companyId":"bayer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"BAY2253651 is a small molecule that targets the CDK9 protein. Used for Relapsed or refractory diffuse large B-cell lymphoma.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}