{"id":"barbexaclone","rwe":[{"pmid":"23981808","year":"2013","title":"End of the barbexaclone era: an experience of treatment withdrawal.","finding":"","journal":"Epileptic disorders : international epilepsy journal with videotape","studyType":"Clinical Study"},{"pmid":"21038181","year":"2010","title":"Barbexaclone abuse in a cannabis ex-user.","finding":"","journal":"Substance abuse","studyType":"Clinical Study"},{"pmid":"14968233","year":"2004","title":"Barbexaclone use in pregnancy.","finding":"","journal":"Saudi medical journal","studyType":"Clinical Study"},{"pmid":"8162392","year":"1993","title":"Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus.","finding":"","journal":"Seizure","studyType":"Clinical Study"},{"pmid":"3320814","year":"1987","title":"[Neurotraumatology and post-traumatic epilepsy. Prevention, treatment and long-term follow-up. Barbexaclone + phenobarbital (maliasin) versus diphenylhydantoin, phenobarbital, primidone, carbamazepine].","finding":"","journal":"Minerva medica","studyType":"Clinical Study"}],"tags":[{"label":"barbexaclone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"N03AA04","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"barbexaclon","offLabel":[],"synonyms":["barbexaclone","barbexaclonum","barbexaclon"],"timeline":[],"brandName":"Barbexaclon","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"barbexaclone","explanation":"Imagine your brain cells are like doors that open and close to let certain messages in or out. Barbexaclon is believed to affect these doors, helping to regulate the flow of information between brain cells. This can potentially help with various conditions, but more research is needed to understand how it works and what benefits it might provide.","oneSentence":"Barbexaclon is thought to work by modulating ion channels in the brain, although the exact details of its mechanism are unclear.","technicalDetail":"Barbexaclon is a small molecule that interacts with ion channels, specifically affecting the activity of certain potassium channels, although the precise molecular mechanisms are not well understood."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4345","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BARBEXACLONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:49:27.688893","biosimilars":[],"competitors":[{"drugName":"primidone","drugSlug":"primidone","fdaApproval":"1954-03-08","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"metharbital","drugSlug":"metharbital","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"barbexaclone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"primidone","brandName":"primidone","genericName":"primidone","approvalYear":"1954","relationship":"same-class"},{"drugId":"metharbital","brandName":"metharbital","genericName":"metharbital","approvalYear":"","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"006247","UNII":"291GX1YB65","INN_ID":"1982","RXNORM":"46795","UMLSCUI":"C0105205","ChEMBL_ID":"CHEMBL3833301","KEGG_DRUG":"D07298","DRUGBANK_ID":"DB09001","PUBCHEM_CID":"71196","MESH_SUPPLEMENTAL_RECORD_UI":"C011019"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":18,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"N03AA04","allCodes":["N03AA04"]},"biosimilarFilings":[],"recentPublications":[{"date":"2013 Sep","pmid":"23981808","title":"End of the barbexaclone era: an experience of treatment withdrawal.","journal":"Epileptic disorders : international epilepsy journal with videotape"},{"date":"2010 Oct","pmid":"21038181","title":"Barbexaclone abuse in a cannabis ex-user.","journal":"Substance abuse"},{"date":"2004 Feb","pmid":"14968233","title":"Barbexaclone use in pregnancy.","journal":"Saudi medical journal"},{"date":"1993 Sep","pmid":"8162392","title":"Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus.","journal":"Seizure"},{"date":"1987 Nov 30","pmid":"3320814","title":"[Neurotraumatology and post-traumatic epilepsy. Prevention, treatment and long-term follow-up. Barbexaclone + phenobarbital (maliasin) versus diphenylhydantoin, phenobarbital, primidone, carbamazepine].","journal":"Minerva medica"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Barbexaclon is a small molecule with an unknown mechanism of action. It is also known by other names, including Barbexaclona, Barbexaclone, Maliasin, and Propylhexedrine L-form Ethylphenylbarbiturate.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}