{"id":"bamipine","rwe":[],"tags":[{"label":"bamipine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Histamine H1 receptor","category":"target"},{"label":"HRH1","category":"gene"},{"label":"D04AA15","category":"atc"},{"label":"Active","category":"status"},{"label":"Urticaria","category":"indication"},{"label":"Histamine Agents","category":"pharmacology"},{"label":"Histamine Antagonists","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"phase_2","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"bamipin","offLabel":[],"synonyms":["piperamine","bamipine dihydrochloride","bamipine lactate","bamipine monohydrochloride","bamipine citrate","bamipine dihydrochloride hydrate","multifungin","bamipine","taumidrine","bamipin"],"timeline":[],"brandName":"Bamipin","ecosystem":[{"indication":"Urticaria","otherDrugs":[{"name":"alimemazine","slug":"alimemazine","company":"Allergan Herbert"},{"name":"antazoline","slug":"antazoline","company":"Novartis"},{"name":"azatadine","slug":"azatadine","company":""},{"name":"brompheniramine","slug":"brompheniramine","company":""}],"globalPrevalence":68000000}],"mechanism":{"target":"Histamine H1 receptor","targets":[{"gene":"HRH1","source":"DrugCentral","target":"Histamine H1 receptor","protein":"Histamine H1 receptor"}],"modality":"Small Molecule","drugClass":"bamipine","explanation":"Imagine your body's immune system is sending out a distress signal, releasing histamine to fight off an allergen. This histamine causes blood vessels to swell and leads to itchy hives. Bamipine acts like a key that locks onto the histamine, preventing it from binding to the H1 receptor and reducing the symptoms of urticaria.","oneSentence":"Bamipine blocks histamine at the H1 receptor to treat urticaria.","technicalDetail":"Bamipine is a competitive antagonist of the histamine H1 receptor, which is a G-protein coupled receptor involved in the regulation of smooth muscle contraction, vascular permeability, and other physiological processes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/288","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BAMIPINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:54:33.275637","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T11:15:37.572257+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"mepyramine","drugSlug":"mepyramine","fdaApproval":"1973-08-07","relationship":"same-class"},{"drugName":"tripelennamine","drugSlug":"tripelennamine","fdaApproval":"1948-02-19","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"promethazine","drugSlug":"promethazine","fdaApproval":"1951-03-29","genericCount":48,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"clemastine","drugSlug":"clemastine","fdaApproval":"1977-02-25","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"pheniramine","drugSlug":"pheniramine","fdaApproval":"1994-06-08","relationship":"same-class"},{"drugName":"diphenhydramine","drugSlug":"diphenhydramine","fdaApproval":"1946-03-04","genericCount":56,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"bamipine","indications":{"approved":[{"name":"Urticaria","source":"DrugCentral","snomedId":126485001,"regulator":"FDA","usPrevalence":null,"globalPrevalence":68000000,"prevalenceMethod":"curated","prevalenceSource":"Allergy, 2020 (PMID:31494963)"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"mepyramine","brandName":"mepyramine","genericName":"mepyramine","approvalYear":"1973","relationship":"same-class"},{"drugId":"tripelennamine","brandName":"tripelennamine","genericName":"tripelennamine","approvalYear":"1948","relationship":"same-class"},{"drugId":"promethazine","brandName":"promethazine","genericName":"promethazine","approvalYear":"1951","relationship":"same-class"},{"drugId":"clemastine","brandName":"clemastine","genericName":"clemastine","approvalYear":"1977","relationship":"same-class"},{"drugId":"pheniramine","brandName":"pheniramine","genericName":"pheniramine","approvalYear":"1994","relationship":"same-class"},{"drugId":"diphenhydramine","brandName":"diphenhydramine","genericName":"diphenhydramine","approvalYear":"1946","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"003726","UNII":"Y6BHZ28O92","CHEBI":"CHEBI:135165","INN_ID":"1285","RXNORM":"18753","UMLSCUI":"C0052946","ChEMBL_ID":"CHEMBL520400","KEGG_DRUG":"D07197","DRUGBANK_ID":"DB13489","PUBCHEM_CID":"72075","SECONDARY_CAS_RN":"61732-85-2","MESH_SUPPLEMENTAL_RECORD_UI":"C020867"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":11,"therapeuticAreas":["Immunology"],"atcClassification":{"source":"DrugCentral","atcCode":"D04AA15","allCodes":["D04AA15","R06AX01"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bamipine (BAMIPINE) is a small molecule drug that targets the histamine H1 receptor. It is used to treat urticaria, a condition characterized by itchy hives. The commercial status of bamipine is currently unknown, and it is not clear if it is patented or available as a generic medication. Bamipine works by blocking the action of histamine at the H1 receptor, which helps to reduce the symptoms of urticaria. Further information on its pharmacokinetics and safety profile is needed.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T11:15:37.572257+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}