{"id":"baicalin","rwe":[],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Lysine-specific histone demethylase 1A","category":"target"},{"label":"KDM1A","category":"gene"},{"label":"PLK1","category":"gene"},{"label":"PREP","category":"gene"},{"label":"Topical","category":"route"},{"label":"Cream","category":"form"},{"label":"Active","category":"status"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Asthmatic Agents","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Enzyme Inhibitors","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Respiratory System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"unknown","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"tj-14","offLabel":[],"synonyms":["tj-14","baicalin"],"timeline":[],"brandName":"Tj-14","ecosystem":[],"mechanism":{"target":"Cyclin-dependent kinase 1, Lysine-specific histone demethylase 1A, Prolyl endopeptidase","targets":[{"gene":"KDM1A","source":"DrugCentral","target":"Lysine-specific histone demethylase 1A","protein":"Lysine-specific histone demethylase 1A"},{"gene":"PLK1","source":"DrugCentral","target":"Serine/threonine-protein kinase PLK1","protein":"Serine/threonine-protein kinase PLK1"},{"gene":"PREP","source":"DrugCentral","target":"Prolyl endopeptidase","protein":"Prolyl endopeptidase"},{"gene":"CDK1","source":"DrugCentral","target":"Cyclin-dependent kinase 1","protein":"Cyclin-dependent kinase 1"},{"gene":"GABRA1","source":"DrugCentral","target":"GABA-A receptor; anion channel","protein":"Gamma-aminobutyric acid receptor subunit alpha-1"},{"gene":"GABRA2","source":"DrugCentral","target":"GABA-A receptor; anion channel","protein":"Gamma-aminobutyric acid receptor subunit alpha-2"},{"gene":"GABRA3","source":"DrugCentral","target":"GABA-A receptor; anion channel","protein":"Gamma-aminobutyric acid receptor subunit alpha-3"},{"gene":"GABRA4","source":"DrugCentral","target":"GABA-A receptor; anion channel","protein":"Gamma-aminobutyric acid receptor subunit alpha-4"},{"gene":"GABRA5","source":"DrugCentral","target":"GABA-A receptor; anion channel","protein":"Gamma-aminobutyric acid receptor subunit alpha-5"},{"gene":"GABRA6","source":"DrugCentral","target":"GABA-A receptor; anion channel","protein":"Gamma-aminobutyric acid receptor subunit alpha-6"}],"modality":"Small Molecule","explanation":"Think of histones like the packaging materials for your genes. LSD1 is like a remover that takes the labels (methyl groups) off the packaging, making it harder for the genes to be turned on. By blocking LSD1, Tj-14 helps keep the labels on, making it easier for the genes to be turned on and potentially leading to changes in how the body works.","oneSentence":"Tj-14 works by blocking the enzyme LSD1, which is involved in turning off genes by removing methyl groups from histones.","technicalDetail":"Tj-14 acts as a competitive inhibitor of LSD1, binding to the enzyme's active site and preventing the removal of methyl groups from histones, thereby modulating gene expression and potentially influencing cellular processes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4055","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=baicalin","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=baicalin","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:54:21.183428","biosimilars":[],"competitors":[{"drugName":"abemaciclib","drugSlug":"abemaciclib","fdaApproval":"2017-09-28","patentExpiry":"Sep 28, 2031","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"dabrafenib","drugSlug":"dabrafenib","fdaApproval":"2013-05-29","patentExpiry":"Oct 15, 2030","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"trilaciclib","drugSlug":"trilaciclib","fdaApproval":"2021-02-12","patentExpiry":"Oct 25, 2031","patentStatus":"Patent protected","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"baicalin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"abemaciclib","brandName":"abemaciclib","genericName":"abemaciclib","approvalYear":"2017","relationship":"same-target"},{"drugId":"dabrafenib","brandName":"dabrafenib","genericName":"dabrafenib","approvalYear":"2013","relationship":"same-target"},{"drugId":"trilaciclib","brandName":"trilaciclib","genericName":"trilaciclib","approvalYear":"2021","relationship":"same-target"}],"trialDetails":[{"nctId":"NCT02445651","phase":"NA","title":"Physiological Effects of Nutritional Support in Patients With Parkinson's Disease","status":"COMPLETED","sponsor":"Thomas Jefferson University","startDate":"2014-03","conditions":["Parkinson Disease","Idiopathic Parkinson Disease"],"enrollment":51,"completionDate":"2022-08-04"},{"nctId":"NCT05994391","phase":"NA","title":"A Prospective, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of LasoperinTM on Cognitive Function in Healthy Adults","status":"COMPLETED","sponsor":"Lindenwood University","startDate":"2022-06-03","conditions":["Cognitive Impairment","Cognitive Decline","Cognition Disorders in Old Age","Well-Being, Psychological","Inflammation","Cognitive Fun"],"enrollment":100,"completionDate":"2022-10-18"},{"nctId":"NCT02737943","phase":"PHASE1","title":"Effect of Mebo Dressing Versus Standard Care on Managing Donor and Recipient Sites of Split-thickness Skin Graft","status":"UNKNOWN","sponsor":"Zagazig University","startDate":"2016-03","conditions":["Burns"],"enrollment":40,"completionDate":"2019-07"},{"nctId":"NCT03728244","phase":"PHASE1,PHASE2","title":"MEBO Ointment and Hyaluronic Acid Gel in the Management of Pain After Free Gingival Graft Harvesting","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2019-02","conditions":["Graft Pain","Gingival Recession"],"enrollment":30,"completionDate":"2020-08"},{"nctId":"NCT01764204","phase":"","title":"Hospital Intensive Monitoring of Adverse Drug Reactions of Qingkailing Injection In The Next Two Years","status":"COMPLETED","sponsor":"China Academy of Chinese Medical Sciences","startDate":"2013-01","conditions":["Adverse Drug Events","Adverse Drug Reactions"],"enrollment":30840,"completionDate":"2018-01"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"route":"Topical","formulation":"Cream","formulations":[{"form":"CREAM","route":"TOPICAL","productName":"Anubis Barcelona"}]},"crossReferences":{"NUI":"N0000179808","NDDF":"008594","UNII":"347Q89U4M5","VUID":"4028922","CHEBI":"CHEBI:2981","VANDF":"4028922","RXNORM":"1440261","UMLSCUI":"C0052929","ChEMBL_ID":"CHEMBL485818","PDB_CHEM_ID":" 0XE","PUBCHEM_CID":"64982","MESH_SUPPLEMENTAL_RECORD_UI":"C038044"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":3266,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Baicalin is a small molecule compound that is the glucuronide of the polyphenolic compound baicalein. It is classified as a small molecule modality.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}