{"id":"bactroban-nasal-ong","safety":{"commonSideEffects":[{"rate":null,"effect":"Nasal irritation"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Rhinitis"},{"rate":null,"effect":"Taste perversion"}]},"_chembl":{"chemblId":"CHEMBL4859559","moleculeType":"Unknown","molecularWeight":"486.43"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Mupirocin works by inhibiting bacterial isoleucyl-tRNA synthetase, an enzyme essential for bacterial protein synthesis. This mechanism is unique among antibiotics and results in bacteriostatic activity against susceptible gram-positive bacteria, particularly Staphylococcus aureus and Streptococcus species. The nasal formulation is used to eradicate nasal carriage of methicillin-resistant Staphylococcus aureus (MRSA) and other pathogenic bacteria.","oneSentence":"Mupirocin is a topical antibiotic that inhibits bacterial protein synthesis by binding to isoleucyl-tRNA synthetase.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:20:22.523Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Eradication of nasal carriage of methicillin-resistant Staphylococcus aureus (MRSA)"},{"name":"Prevention of staphylococcal nasal colonization"}]},"trialDetails":[{"nctId":"NCT03962907","phase":"PHASE4","title":"Preoperative Decolonization and Surgical Site Infections in Orthopaedic Surgery - 2 Year Outcome in Prosthetic Surgery","status":"COMPLETED","sponsor":"Lindenhofgruppe AG","startDate":"2019-01-01","conditions":"Staphylococcus Aureus, Orthopaedic Surgery, Surgical Site Infection","enrollment":1318}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"BACTROBAN® Nasal ong","genericName":"BACTROBAN® Nasal ong","companyName":"Lindenhofgruppe AG","companyId":"lindenhofgruppe-ag","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mupirocin is a topical antibiotic that inhibits bacterial protein synthesis by binding to isoleucyl-tRNA synthetase. Used for Eradication of nasal carriage of methicillin-resistant Staphylococcus aureus (MRSA), Prevention of staphylococcal nasal colonization.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}