{"id":"baclofen-ir","safety":{"commonSideEffects":[{"rate":"10-30%","effect":"Drowsiness"},{"rate":"10-30%","effect":"Dizziness"},{"rate":"5-20%","effect":"Nausea"},{"rate":"5-20%","effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Baclofen IR works by activating GABA_B receptors in the central nervous system, which leads to a decrease in muscle tone and spasticity. This results in relief from symptoms associated with conditions such as multiple sclerosis and spinal cord injuries.","oneSentence":"Baclofen IR is a central nervous system depressant that acts as a GABA_B receptor agonist.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T03:22:07.678Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Spasticity associated with multiple sclerosis"},{"name":"Spasticity associated with spinal cord injuries"}]},"trialDetails":[{"nctId":"NCT00914290","phase":"PHASE2","title":"A Study With IPX056 in Subjects With Spasticity Associated With Multiple Sclerosis","status":"COMPLETED","sponsor":"Impax Laboratories, LLC","startDate":"2009-04","conditions":"Spasticity, Multiple Sclerosis","enrollment":23},{"nctId":"NCT00802035","phase":"PHASE1","title":"ALK29-002: A Study of Baclofen Formulations in Healthy Adults","status":"COMPLETED","sponsor":"Alkermes, Inc.","startDate":"2008-11","conditions":"Alcohol Dependence","enrollment":16}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["CAS Registry Number [11134-47-0]"],"phase":"phase_2","status":"active","brandName":"Baclofen IR","genericName":"Baclofen IR","companyName":"Impax Laboratories, LLC","companyId":"impax-laboratories-llc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Baclofen IR is a central nervous system depressant that acts as a GABA_B receptor agonist. Used for Spasticity associated with multiple sclerosis, Spasticity associated with spinal cord injuries.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}