{"id":"baclofen-amitriptyline-ketamine-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation or erythema"},{"rate":null,"effect":"Dizziness or sedation (systemic absorption)"},{"rate":null,"effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL1200964","moleculeType":"Small molecule","molecularWeight":"313.87"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Baclofen acts as a GABA-B receptor agonist to reduce neuronal excitability and muscle spasticity. Amitriptyline inhibits reuptake of norepinephrine and serotonin, enhancing descending pain inhibition. Ketamine blocks NMDA receptors, reducing central sensitization and neuropathic pain signaling. The combination targets pain through multiple mechanisms when applied topically.","oneSentence":"This triple-agent topical gel combines a GABA-B agonist (baclofen), a tricyclic antidepressant (amitriptyline), and a dissociative anesthetic (ketamine) to provide multimodal analgesia for neuropathic pain.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:03:27.572Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cancer-related neuropathic pain (Phase 3)"}]},"trialDetails":[{"nctId":"NCT00516503","phase":"PHASE3","title":"Baclofen-Amitriptyline Hydrochloride-Ketamine Gel in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer","status":"COMPLETED","sponsor":"Alliance for Clinical Trials in Oncology","startDate":"2008-02","conditions":"Chronic Myeloproliferative Disorders, Leukemia, Lymphoma","enrollment":208}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"baclofen/amitriptyline/ketamine gel","genericName":"baclofen/amitriptyline/ketamine gel","companyName":"Alliance for Clinical Trials in Oncology","companyId":"alliance-for-clinical-trials-in-oncology","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This triple-agent topical gel combines a GABA-B agonist (baclofen), a tricyclic antidepressant (amitriptyline), and a dissociative anesthetic (ketamine) to provide multimodal analgesia for neuropathic pain. Used for Cancer-related neuropathic pain (Phase 3).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}