{"id":"bacitracin","rwe":[{"pmid":"41892540","year":"2026","title":"Characterization of Polysaccharide-Based Composites Enriched with Zinc Oxide and Bacitracin for the Treatment of Infected Wounds.","finding":"","journal":"Gels (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41875433","year":"2026","title":"Antibiotic Repurposing: Conjugation of the Gram-Positive Only Peptide Antibiotic Bacitracin to a Bis-Catechol Siderophore Mimetic Imparts Potent Activity against Multi-Drug Resistant Acinetobacter baumannii.","finding":"","journal":"ACS infectious diseases","studyType":"Clinical Study"},{"pmid":"41846420","year":"2026","title":"Green synthesis of a bacitracin@Ag-CeO(2) nanocomposite@hydrogel for dual antibiofilm and anti-inflammatory therapy against MRSA wound infections.","finding":"","journal":"Journal of materials chemistry. B","studyType":"Clinical Study"},{"pmid":"41846321","year":"2026","title":"Comparison of antimicrobial susceptibility testing of Clostridium perfringens by agar dilution and broth microdilution methods.","finding":"","journal":"Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc","studyType":"Clinical Study"},{"pmid":"41828921","year":"2026","title":"The Combination of Different Dietary Fiber Sources Improves the Growth Performance, Nutrient Digestibility and Intestinal Function in Broilers from 1 to 42 d of Age.","finding":"","journal":"Animals : an open access journal from MDPI","studyType":"Clinical Study"}],"_fda":{"id":"3aea3e3c-519b-7eb7-e063-6394a90a0c71","set_id":"0070ea5f-434d-53a7-e063-6294a90abf18","openfda":{"unii":["89Y4M234ES","057Y626693","19371312D4"],"route":["TOPICAL"],"rxcui":["204602"],"spl_id":["3aea3e3c-519b-7eb7-e063-6394a90a0c71"],"brand_name":["health and .beyond Triple 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away."],"package_label_principal_display_panel":["image description"]},"tags":[{"label":"bacitracin","category":"class"},{"label":"Biologic","category":"modality"},{"label":"Tyrosine-protein kinase Lck","category":"target"},{"label":"LCK","category":"gene"},{"label":"EGFR","category":"gene"},{"label":"D06AX05","category":"atc"},{"label":"Topical","category":"route"},{"label":"Cream","category":"form"},{"label":"Off-Patent","category":"patent"},{"label":"Generic Available","category":"availability"},{"label":"Established","category":"status"},{"label":"Bacterial keratitis","category":"indication"},{"label":"Blepharoconjunctivitis","category":"indication"},{"label":"Corneal abrasion","category":"indication"},{"label":"Infective blepharitis","category":"indication"},{"label":"Keratitis","category":"indication"},{"label":"Minor Bacterial Skin Infections","category":"indication"},{"label":"Pharmacia And Upjohn","category":"company"},{"label":"Approved 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Ocular Infection","otherDrugs":[{"name":"Polymyxin B","slug":"polymyxin-b","company":"Monarch Pharms"},{"name":"chloramphenicol","slug":"chloramphenicol","company":"Parkedale"},{"name":"cortisone acetate","slug":"cortisone-acetate","company":""},{"name":"erythromycin","slug":"erythromycin","company":"Arbor Pharms Llc"}],"globalPrevalence":6000000}],"mechanism":{"target":"Tyrosine-protein kinase Lck","novelty":"First-in-class","targets":[{"gene":"LCK","source":"DrugCentral","target":"Tyrosine-protein kinase Lck","protein":"Tyrosine-protein kinase Lck"},{"gene":"EGFR","source":"DrugCentral","target":"Epidermal growth factor receptor","protein":"Epidermal growth factor receptor"}],"modality":"Small Molecule","drugClass":"bacitracin","explanation":"","oneSentence":"","technicalDetail":"Cortisporin exerts its antibacterial effects by inhibiting the enzyme bactoprenol, which is essential for the synthesis of peptidoglycan, a key component of bacterial cell walls."},"commercial":{"launchDate":"1948","_launchSource":"DrugCentral (FDA 1948-07-29, PHARMACIA AND UPJOHN)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/281","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=BACITRACIN","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BACITRACIN","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange 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