{"id":"bacampicillin","rwe":[{"pmid":"40183908","year":"2025","title":"Pharmacokinetics and oral bioavailability of ampicillin and its prodrug bacampicillin in chickens and turkeys.","finding":"","journal":"Journal of veterinary science","studyType":"Clinical Study"},{"pmid":"30000142","year":"2006","title":"Bacampicillin.","finding":"","journal":"","studyType":"Clinical Study"},{"pmid":"27639454","year":"2016","title":"Antimicrobial drug use in primary healthcare clinics: a retrospective evaluation.","finding":"","journal":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases","studyType":"Clinical Study"},{"pmid":"21196760","year":"2011","title":"Tolerability of aztreonam in patients with cell-mediated allergy to β-lactams.","finding":"","journal":"International archives of allergy and immunology","studyType":"Clinical Study"},{"pmid":"17603179","year":"2007","title":"Bacampicillin uptake is shared with thiamine in Caco-2 cells.","finding":"","journal":"Biological & pharmaceutical bulletin","studyType":"Clinical Study"}],"tags":[{"label":"bacampicillin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"J01CA06","category":"atc"},{"label":"Off-Patent","category":"patent"},{"label":"Active","category":"status"},{"label":"Gonorrhea","category":"indication"},{"label":"Haemophilus influenzae pneumonia","category":"indication"},{"label":"Infection of skin AND/OR subcutaneous tissue","category":"indication"},{"label":"Infective otitis media","category":"indication"},{"label":"Pharyngitis","category":"indication"},{"label":"Sinusitis","category":"indication"},{"label":"Approved 1980s","category":"decade"},{"label":"Anti-Bacterial Agents","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"}],"phase":"marketed","safety":{"commonSideEffects":[],"contraindications":["Infectious mononucleosis","Kidney disease","Pseudomembranous enterocolitis"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_fixedAt":"2026-03-30T11:51:13.940404","_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=BACAMPICILLIN","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-19T23:42:47.663882+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-19T23:42:53.412128+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BACAMPICILLIN","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-19T23:42:53.714053+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1583/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-19T23:42:54.425770+00:00"}},"allNames":"carampicillin","offLabel":[],"synonyms":["bacampicillin","bacampicillin hydrochloride","carampicillin","bacampicillin HCl"],"timeline":[{"date":"1980-12-22","type":"positive","source":"DrugCentral","milestone":"FDA approval"},{"date":"1982-03-23","type":"positive","source":"FDA Orange Book","milestone":"Spectrobid approved — 125MG/5ML"}],"brandName":"Carampicillin","ecosystem":[{"indication":"Gonorrhea","otherDrugs":[{"name":"amphotericin B","slug":"amphotericin-b","company":"Apothecon"},{"name":"ampicillin","slug":"ampicillin","company":"Wyeth Ayerst"},{"name":"cefixime","slug":"cefixime","company":""},{"name":"cefoxitin","slug":"cefoxitin","company":""}],"globalPrevalence":null},{"indication":"Haemophilus influenzae pneumonia","otherDrugs":[{"name":"alatrofloxacin","slug":"alatrofloxacin","company":"Pfizer"},{"name":"amoxicillin","slug":"amoxicillin","company":"Apothecon"},{"name":"ampicillin","slug":"ampicillin","company":"Wyeth Ayerst"},{"name":"azithromycin","slug":"azithromycin","company":""}],"globalPrevalence":null},{"indication":"Infection of skin AND/OR subcutaneous tissue","otherDrugs":[{"name":"alatrofloxacin","slug":"alatrofloxacin","company":"Pfizer"},{"name":"amikacin","slug":"amikacin","company":"Apothecon"},{"name":"amoxicillin","slug":"amoxicillin","company":"Apothecon"},{"name":"amphotericin B","slug":"amphotericin-b","company":"Apothecon"}],"globalPrevalence":null},{"indication":"Infective otitis media","otherDrugs":[{"name":"amoxicillin","slug":"amoxicillin","company":"Apothecon"},{"name":"amphotericin B","slug":"amphotericin-b","company":"Apothecon"},{"name":"ampicillin","slug":"ampicillin","company":"Wyeth Ayerst"},{"name":"azithromycin","slug":"azithromycin","company":""}],"globalPrevalence":null},{"indication":"Pharyngitis","otherDrugs":[{"name":"amoxicillin","slug":"amoxicillin","company":"Apothecon"},{"name":"amphotericin B","slug":"amphotericin-b","company":"Apothecon"},{"name":"ampicillin","slug":"ampicillin","company":"Wyeth Ayerst"},{"name":"benzylpenicillin","slug":"benzylpenicillin","company":"Pfizer"}],"globalPrevalence":null},{"indication":"Sinusitis","otherDrugs":[{"name":"amphotericin B","slug":"amphotericin-b","company":"Apothecon"},{"name":"ampicillin","slug":"ampicillin","company":"Wyeth Ayerst"},{"name":"cloxacillin","slug":"cloxacillin","company":"Glaxosmithkline"},{"name":"demeclocycline","slug":"demeclocycline","company":"Lederle"}],"globalPrevalence":null},{"indication":"Urinary tract infectious disease","otherDrugs":[{"name":"Polymyxin B","slug":"polymyxin-b","company":"Monarch Pharms"},{"name":"acetohydroxamic acid","slug":"acetohydroxamic-acid","company":"Mission Pharma"},{"name":"alatrofloxacin","slug":"alatrofloxacin","company":"Pfizer"},{"name":"amoxicillin","slug":"amoxicillin","company":"Apothecon"}],"globalPrevalence":null}],"mechanism":{"novelty":"Follow-on","modality":"Small Molecule","drugClass":"bacampicillin","explanation":"","oneSentence":"","technicalDetail":"Bacampicillin is a beta-lactam antibiotic that exerts its antibacterial effect by binding to penicillin-binding proteins (PBPs) located inside bacterial cell walls, thereby inhibiting the synthesis of peptidoglycan, a critical component of the bacterial cell wall."},"commercial":{"launchDate":"1980","_launchSource":"DrugCentral (FDA 1980-12-22, )"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/280","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=BACAMPICILLIN","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=BACAMPICILLIN","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange Book"}],"_enrichedAt":"2026-03-30T08:48:59.495458","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-19T23:42:56.094140+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"ampicillin","drugSlug":"ampicillin","fdaApproval":"1965-12-17","genericCount":18,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"carbenicillin","drugSlug":"carbenicillin","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"amoxicillin","drugSlug":"amoxicillin","fdaApproval":"1974-12-09","patentExpiry":"May 7, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"carindacillin","drugSlug":"carindacillin","fdaApproval":"1972-10-26","relationship":"same-class"},{"drugName":"azlocillin","drugSlug":"azlocillin","fdaApproval":"1982-09-03","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"mezlocillin","drugSlug":"mezlocillin","fdaApproval":"1981-09-21","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"mecillinam","drugSlug":"mecillinam","fdaApproval":"","relationship":"same-class"},{"drugName":"piperacillin","drugSlug":"piperacillin","fdaApproval":"1981-12-29","genericCount":2,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"ticarcillin","drugSlug":"ticarcillin","fdaApproval":"1976-11-09","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"hetacillin","drugSlug":"hetacillin","fdaApproval":"","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"bacampicillin","indications":{"approved":[{"name":"Gonorrhea","source":"DrugCentral","snomedId":15628003,"regulator":"FDA"},{"name":"Haemophilus influenzae pneumonia","source":"DrugCentral","snomedId":70036007,"regulator":"FDA"},{"name":"Infection of skin AND/OR subcutaneous tissue","source":"DrugCentral","snomedId":19824006,"regulator":"FDA"},{"name":"Infective otitis media","source":"DrugCentral","snomedId":312218008,"regulator":"FDA"},{"name":"Pharyngitis","source":"DrugCentral","snomedId":405737000,"regulator":"FDA"},{"name":"Sinusitis","source":"DrugCentral","snomedId":36971009,"regulator":"FDA"},{"name":"Urinary tract infectious disease","source":"DrugCentral","snomedId":68566005,"regulator":"FDA"}],"offLabel":[{"name":"Cholangitis","source":"DrugCentral","drugName":"BACAMPICILLIN","evidenceCount":0,"evidenceLevel":"emerging"}],"pipeline":[]},"_fixedFields":["pubmed(232)"],"drugCategory":"active","labelChanges":[],"patentStatus":"Off-patent — no active Orange Book patents","relatedDrugs":[{"drugId":"ampicillin","brandName":"ampicillin","genericName":"ampicillin","approvalYear":"1965","relationship":"same-class"},{"drugId":"carbenicillin","brandName":"carbenicillin","genericName":"carbenicillin","approvalYear":"","relationship":"same-class"},{"drugId":"amoxicillin","brandName":"amoxicillin","genericName":"amoxicillin","approvalYear":"1974","relationship":"same-class"},{"drugId":"carindacillin","brandName":"carindacillin","genericName":"carindacillin","approvalYear":"1972","relationship":"same-class"},{"drugId":"azlocillin","brandName":"azlocillin","genericName":"azlocillin","approvalYear":"1982","relationship":"same-class"},{"drugId":"mezlocillin","brandName":"mezlocillin","genericName":"mezlocillin","approvalYear":"1981","relationship":"same-class"},{"drugId":"mecillinam","brandName":"mecillinam","genericName":"mecillinam","approvalYear":"","relationship":"same-class"},{"drugId":"piperacillin","brandName":"piperacillin","genericName":"piperacillin","approvalYear":"1981","relationship":"same-class"},{"drugId":"ticarcillin","brandName":"ticarcillin","genericName":"ticarcillin","approvalYear":"1976","relationship":"same-class"},{"drugId":"hetacillin","brandName":"hetacillin","genericName":"hetacillin","approvalYear":"","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT02099240","phase":"EARLY_PHASE1","title":"Patients Response to Early Switch To Oral:Osteomyelitis Study","status":"TERMINATED","sponsor":"Julio Ramirez","startDate":"2014-03-06","conditions":["Osteomyelitis"],"enrollment":11,"completionDate":"2018-11-07"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"_patentsChecked":true,"crossReferences":{"NUI":"N0000147716","MMSL":"4240","NDDF":"002709","UNII":"8GM2J22278","VUID":"4019623","CHEBI":"CHEBI:2968","VANDF":"4018505","INN_ID":"3630","RXNORM":"18687","UMLSCUI":"C0052865","chemblId":"CHEMBL1583","ChEMBL_ID":"CHEMBL1583","KEGG_DRUG":"D00927","DRUGBANK_ID":"DB01602","PUBCHEM_CID":"441397","SNOMEDCT_US":"23176001","IUPHAR_LIGAND_ID":"12292","SECONDARY_CAS_RN":"37661-08-8","MESH_SUPPLEMENTAL_RECORD_UI":"C011674"},"formularyStatus":[],"_enricherVersion":"v2","_offLabelChecked":true,"developmentCodes":[],"ownershipHistory":[],"publicationCount":232,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"J01CA06","allCodes":["J01CA06"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025 Mar","pmid":"40183908","title":"Pharmacokinetics and oral bioavailability of ampicillin and its prodrug bacampicillin in chickens and turkeys.","journal":"Journal of veterinary science"},{"date":"2006","pmid":"30000142","title":"Bacampicillin.","journal":""},{"date":"2016 Nov","pmid":"27639454","title":"Antimicrobial drug use in primary healthcare clinics: a retrospective evaluation.","journal":"International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases"},{"date":"2011","pmid":"21196760","title":"Tolerability of aztreonam in patients with cell-mediated allergy to β-lactams.","journal":"International archives of allergy and immunology"},{"date":"2007 Jul","pmid":"17603179","title":"Bacampicillin uptake is shared with thiamine in Caco-2 cells.","journal":"Biological & pharmaceutical bulletin"}],"companionDiagnostics":[],"genericManufacturers":0,"_genericFilersChecked":true,"genericManufacturerList":[],"status":"approved","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"1980","aiSummary":"","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-19T23:42:56.094140+00:00","fieldsConflicting":1,"overallConfidence":0.8},"verificationStatus":"partial","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":true,"score":2}}