{"id":"azt","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Bone marrow suppression (anemia, neutropenia)"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Nausea"},{"rate":"5-10","effect":"Fatigue"},{"rate":"<1","effect":"Lactic acidosis"},{"rate":"variable","effect":"Lipoatrophy"}]},"_chembl":{"chemblId":"CHEMBL178240","moleculeType":"Small molecule","molecularWeight":"267.24"},"_dailymed":{"setId":"9a105eaf-ee77-4016-beeb-d425a5565db2","title":"AZACTAM (AZTREONAM) INJECTION, POWDER, FOR SOLUTION [E.R. SQUIBB & SONS, L.L.C.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"AZT is a nucleoside reverse transcriptase inhibitor (NRTI) that acts as a chain terminator during HIV DNA synthesis. When incorporated into the growing DNA chain by reverse transcriptase, it lacks a 3'-OH group, causing premature chain termination and blocking viral replication. This was the first antiretroviral drug approved for HIV treatment and remains part of combination antiretroviral therapy regimens.","oneSentence":"AZT (zidovudine) inhibits HIV reverse transcriptase, preventing the virus from converting its RNA genome into DNA and replicating within host cells.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:03:19.208Z","_scrapedBy":"cloudflare-swarm","_wikipedia":{"url":"https://en.wikipedia.org/wiki/Zidovudine","title":"Zidovudine","extract":"Zidovudine (ZDV), also known as azidothymidine (AZT), was the first antiretroviral medication used to prevent and treat HIV/AIDS. It is generally recommended for use in combination with other antiretrovirals. It may be used to prevent mother-to-child spread during birth or after a needlestick injury or other potential exposure. It is sold both by itself and together as lamivudine/zidovudine and abacavir/lamivudine/zidovudine. 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