{"id":"azosemide","rwe":[],"tags":[{"label":"azosemide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Congestive heart failure","category":"indication"},{"label":"Diuretics","category":"pharmacology"},{"label":"Natriuretic Agents","category":"pharmacology"}],"phase":"phase_3","safety":{"safetySignals":[{"llr":528.022,"date":"","count":288,"signal":"Cardiac failure","source":"DrugCentral FAERS","actionTaken":"Reported 288 times (LLR=528)"},{"llr":354.056,"date":"","count":225,"signal":"Renal impairment","source":"DrugCentral FAERS","actionTaken":"Reported 225 times (LLR=354)"},{"llr":216.292,"date":"","count":71,"signal":"Cardiac failure chronic","source":"DrugCentral FAERS","actionTaken":"Reported 71 times (LLR=216)"},{"llr":150.875,"date":"","count":97,"signal":"Hepatic function abnormal","source":"DrugCentral FAERS","actionTaken":"Reported 97 times (LLR=151)"},{"llr":143.861,"date":"","count":80,"signal":"Cerebral infarction","source":"DrugCentral FAERS","actionTaken":"Reported 80 times (LLR=144)"},{"llr":137.556,"date":"","count":105,"signal":"Blood pressure decreased","source":"DrugCentral FAERS","actionTaken":"Reported 105 times (LLR=138)"},{"llr":119.9,"date":"","count":48,"signal":"Concomitant disease aggravated","source":"DrugCentral FAERS","actionTaken":"Reported 48 times (LLR=120)"},{"llr":108.493,"date":"","count":41,"signal":"Brain natriuretic peptide increased","source":"DrugCentral FAERS","actionTaken":"Reported 41 times (LLR=108)"},{"llr":101.364,"date":"","count":53,"signal":"Pulmonary arterial hypertension","source":"DrugCentral FAERS","actionTaken":"Reported 53 times (LLR=101)"},{"llr":98.521,"date":"","count":63,"signal":"Altered state of consciousness","source":"DrugCentral FAERS","actionTaken":"Reported 63 times (LLR=99)"},{"llr":96.243,"date":"","count":45,"signal":"Cardiac failure acute","source":"DrugCentral FAERS","actionTaken":"Reported 45 times (LLR=96)"},{"llr":95.77,"date":"","count":48,"signal":"Right ventricular failure","source":"DrugCentral FAERS","actionTaken":"Reported 48 times (LLR=96)"},{"llr":89.414,"date":"","count":178,"signal":"Anaemia","source":"DrugCentral FAERS","actionTaken":"Reported 178 times (LLR=89)"},{"llr":88.146,"date":"","count":97,"signal":"Pleural effusion","source":"DrugCentral FAERS","actionTaken":"Reported 97 times (LLR=88)"},{"llr":85.536,"date":"","count":84,"signal":"Interstitial lung disease","source":"DrugCentral FAERS","actionTaken":"Reported 84 times (LLR=86)"}],"commonSideEffects":[{"effect":"Cardiac failure","drugRate":"LLR 528","severity":"serious"},{"effect":"Renal impairment","drugRate":"LLR 354","severity":"common"},{"effect":"Cardiac failure chronic","drugRate":"LLR 216","severity":"common"},{"effect":"Hepatic function abnormal","drugRate":"LLR 151","severity":"common"},{"effect":"Cerebral infarction","drugRate":"LLR 144","severity":"common"},{"effect":"Blood pressure decreased","drugRate":"LLR 138","severity":"common"},{"effect":"Concomitant disease aggravated","drugRate":"LLR 120","severity":"common"},{"effect":"Brain natriuretic peptide increased","drugRate":"LLR 108","severity":"common"},{"effect":"Pulmonary arterial hypertension","drugRate":"LLR 101","severity":"common"},{"effect":"Altered state of consciousness","drugRate":"LLR 99","severity":"common"},{"effect":"Cardiac failure acute","drugRate":"LLR 96","severity":"common"},{"effect":"Right ventricular failure","drugRate":"LLR 96","severity":"common"},{"effect":"Anaemia","drugRate":"LLR 89","severity":"common"},{"effect":"Pleural effusion","drugRate":"LLR 88","severity":"common"},{"effect":"Interstitial lung disease","drugRate":"LLR 86","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"azosemid","offLabel":[],"synonyms":["azosemide","diurapid","azosemid"],"timeline":[],"brandName":"Azosemid","ecosystem":[{"indication":"Congestive heart failure","otherDrugs":[{"name":"acetyldigitoxin","slug":"acetyldigitoxin","company":"Novartis"},{"name":"enalapril","slug":"enalapril","company":"Valeant Pharms North"},{"name":"enalaprilat","slug":"enalaprilat","company":"Biovail Labs Intl"},{"name":"ubidecarenone","slug":"ubidecarenone","company":""}],"globalPrevalence":64000000}],"mechanism":{"modality":"Small Molecule","drugClass":"azosemide","explanation":"Think of it like a sponge: when you squeeze a sponge, water comes out. Azosemide helps the kidneys squeeze out excess water and salt by blocking the tiny tubes where they're reabsorbed, allowing more to be excreted in the urine.","oneSentence":"Azosemide works by inhibiting the reabsorption of sodium and chloride ions in the kidneys.","technicalDetail":"Azosemide acts as a loop diuretic, inhibiting the sodium-potassium-chloride cotransporter (NKCC2) in the thick ascending limb of the loop of Henle, leading to increased sodium and chloride excretion and subsequent diuresis."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/278","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=AZOSEMIDE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=AZOSEMIDE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:53:59.644192","biosimilars":[],"competitors":[],"genericName":"azosemide","indications":{"approved":[{"name":"Congestive heart failure","source":"DrugCentral","snomedId":42343007,"regulator":"FDA","usPrevalence":6200000,"globalPrevalence":64000000,"prevalenceMethod":"curated","prevalenceSource":"ESC Heart Failure, 2023"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT00355667","phase":"PHASE4","title":"Comparison of Long- and Short-acting Diuretics in Congestive Heart Failure","status":"COMPLETED","sponsor":"Hyogo Medical University","startDate":"2006-06","conditions":["Congestive Heart Failure"],"enrollment":320,"completionDate":"2010-08"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"007033","UNII":"MR40VT1L8Z","CHEBI":"CHEBI:31248","INN_ID":"3954","RXNORM":"18651","UMLSCUI":"C0052820","ChEMBL_ID":"CHEMBL1097235","KEGG_DRUG":"D01323","DRUGBANK_ID":"DB08961","PDB_CHEM_ID":" IWE","PUBCHEM_CID":"2273","MESH_SUPPLEMENTAL_RECORD_UI":"C018222"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","clearance":"1.483 mL/min/kg","bioavailability":"10%","volumeOfDistribution":"0.278 L/kg"},"publicationCount":112,"therapeuticAreas":["Cardiovascular"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Azosemide, a small molecule drug in the azosemide class, is used to treat Congestive heart failure. Its mechanism of action is not well-documented, but it is believed to work by inhibiting the reabsorption of sodium and chloride ions in the kidneys, leading to increased urine production and reduced fluid buildup in the body. The commercial status of azosemide is unclear, but it is not widely available in the US market. Key safety considerations include its low bioavailability of 10%, which may affect its efficacy. Further research is needed to fully understand its pharmacological properties.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}