{"id":"azm-x-mg-aml-y-mg","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Peripheral edema"},{"rate":null,"effect":"Hyperkalemia (azilsartan component)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Azilsartan blocks angiotensin II type 1 receptors, preventing vasoconstriction and aldosterone release, while amlodipine inhibits L-type calcium channels in vascular smooth muscle to promote vasodilation. This combination provides additive antihypertensive effects through dual mechanisms targeting the renin-angiotensin system and calcium-dependent vascular tone.","oneSentence":"AZM (azilsartan) is an angiotensin II receptor blocker and AML (amlodipine) is a calcium channel blocker; together they reduce blood pressure through complementary vasodilatory pathways.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:03:26.057Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypertension (essential hypertension in adults)"}]},"trialDetails":[{"nctId":"NCT05385770","phase":"PHASE3","title":"Study to Evaluate and Compare the Efficacy and Safety of AZM and AML Combined and Alone in Mild-to-moderate Essential Hypertensive Subjects","status":"COMPLETED","sponsor":"Celltrion","startDate":"2022-07-08","conditions":"Essential Hypertension","enrollment":890}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"AZM X mg + AML Y mg","genericName":"AZM X mg + AML Y mg","companyName":"Celltrion","companyId":"celltrion","modality":"Small molecule","firstApprovalDate":"","aiSummary":"AZM (azilsartan) is an angiotensin II receptor blocker and AML (amlodipine) is a calcium channel blocker; together they reduce blood pressure through complementary vasodilatory pathways. Used for Hypertension (essential hypertension in adults).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}