{"id":"azithromycin-sulphadoxine-pyrimethamine-llin","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance (nausea, diarrhea)"},{"rate":null,"effect":"Rash"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Allergic reactions (sulphonamide sensitivity)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Azithromycin is a macrolide antibiotic with antimalarial properties that inhibits parasite protein synthesis. Sulphadoxine-pyrimethamine is a fixed-dose antimalarial combination that inhibits folate metabolism in Plasmodium parasites. LLINs provide physical and chemical barrier protection against mosquito vectors. Together, this combination addresses malaria through chemoprophylaxis and vector control.","oneSentence":"This combination uses azithromycin (antibiotic), sulphadoxine-pyrimethamine (antimalarial), and long-lasting insecticidal nets (LLIN) to prevent and treat malaria through multiple mechanisms including parasite inhibition and mosquito vector control.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:03:27.222Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Malaria prevention and treatment in endemic regions"},{"name":"Intermittent preventive treatment in pregnancy (IPTp) or infants (IPTi)"}]},"trialDetails":[{"nctId":"NCT01136850","phase":"PHASE3","title":"Intermittent Preventive Treatment With Azithromycin-containing Regimens in Pregnant Women in Papua New Guinea","status":"COMPLETED","sponsor":"University of Melbourne","startDate":"2009-11","conditions":"Malaria in Pregnancy, Sexually Transmitted Infections, Anaemia","enrollment":2793}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Zithromax","sulfadoxine-pyrimethamine"],"phase":"phase_3","status":"active","brandName":"azithromycin, sulphadoxine pyrimethamine, LLIN","genericName":"azithromycin, sulphadoxine pyrimethamine, LLIN","companyName":"University of Melbourne","companyId":"university-of-melbourne","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination uses azithromycin (antibiotic), sulphadoxine-pyrimethamine (antimalarial), and long-lasting insecticidal nets (LLIN) to prevent and treat malaria through multiple mechanisms including parasite inhibition and mosquito vector control. Used for Malaria prevention and treatment in endemic regions, Intermittent preventive treatment in pregnancy (IPTp) or infants (IPTi).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}