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Together, this combination provides synergistic coverage against mixed aerobic and anaerobic infections.","oneSentence":"Azithromycin inhibits bacterial protein synthesis while metronidazole disrupts anaerobic bacterial DNA, providing broad-spectrum antimicrobial coverage.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:39:44.968Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mixed aerobic-anaerobic bacterial infections"},{"name":"Intra-abdominal infections"},{"name":"Pelvic inflammatory disease"},{"name":"Polymicrobial infections"}]},"trialDetails":[{"nctId":"NCT07445282","phase":"PHASE4","title":"This Randomized Controlled Trial Evaluates the Comparative Efficacy of Intravenous Meropenem Alone Versus Intravenous Meropenem Combined With Oral Azithromycin in Children Aged 6 Months to Under 5 Years Diagnosed With Blood Culture-confirmed Extensively Drug-resistant Uncomplicated Typhoid Fever","status":"COMPLETED","sponsor":"Sheikh Zayed 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