{"id":"azidamfenicol","rwe":[],"tags":[{"label":"azidamfenicol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"S01AA25","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{"commonSideEffects":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_fixedAt":"2026-03-30T16:34:02.261262","allNames":"azidamphenicol","offLabel":[],"synonyms":["azidamfenicol","azidamphenicol","azidoamphenicol"],"timeline":[],"brandName":"Azidamphenicol","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"azidamfenicol","explanation":"Imagine your body's cells are like factories that make proteins to keep you healthy. Bacteria are like tiny factories that make proteins too, but they're bad for you. Azidamfenicol is like a special tool that blocks the bacteria's factories from making proteins, which ultimately kills them.","oneSentence":"Azidamfenicol works by binding to the 50S ribosomal subunit of bacteria, preventing the formation of peptide bonds and thereby inhibiting protein synthesis.","technicalDetail":"Azidamfenicol binds to the 50S ribosomal subunit of bacteria, specifically to the peptidyl transferase center, which is essential for peptide bond formation. This binding action prevents the formation of peptide bonds, thereby inhibiting protein synthesis and ultimately leading to bacterial cell death."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3011","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=AZIDAMFENICOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T08:48:03.024189","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:49:57.897178+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[{"drugName":"chloramphenicol","drugSlug":"chloramphenicol","fdaApproval":"1950-12-08","genericCount":7,"patentStatus":"Off-patent — generic 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available","relationship":"same-class"},{"drugName":"vancomycin","drugSlug":"vancomycin","fdaApproval":"1964-11-06","patentExpiry":"Nov 6, 2035","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"azidamfenicol","indications":{"approved":[],"offLabel":[],"pipeline":[]},"_fixedFields":["pubmed(3)"],"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"chloramphenicol","brandName":"chloramphenicol","genericName":"chloramphenicol","approvalYear":"1950","relationship":"same-class"},{"drugId":"chlortetracycline","brandName":"chlortetracycline","genericName":"chlortetracycline","approvalYear":"1950","relationship":"same-class"},{"drugId":"neomycin","brandName":"neomycin","genericName":"neomycin","approvalYear":"1957","relationship":"same-class"},{"drugId":"oxytetracycline","brandName":"oxytetracycline","genericName":"oxytetracycline","approvalYear":"1964","relationship":"same-class"},{"drugId":"tetracycline","brandName":"tetracycline","genericName":"tetracycline","approvalYear":"1953","relationship":"same-class"},{"drugId":"natamycin","brandName":"natamycin","genericName":"natamycin","approvalYear":"1978","relationship":"same-class"},{"drugId":"gentamicin","brandName":"gentamicin","genericName":"gentamicin","approvalYear":"1970","relationship":"same-class"},{"drugId":"tobramycin","brandName":"tobramycin","genericName":"tobramycin","approvalYear":"1975","relationship":"same-class"},{"drugId":"benzylpenicillin","brandName":"benzylpenicillin","genericName":"benzylpenicillin","approvalYear":"1947","relationship":"same-class"},{"drugId":"dihydrostreptomycin","brandName":"dihydrostreptomycin","genericName":"dihydrostreptomycin","approvalYear":"","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"006603","UNII":"40257685LM","CHEBI":"CHEBI:135238","INN_ID":"1703","UMLSCUI":"C0771992","ChEMBL_ID":"CHEMBL3989525","KEGG_DRUG":"D07411","DRUGBANK_ID":"DB13294","PUBCHEM_CID":"62858","IUPHAR_LIGAND_ID":"12397","MESH_SUPPLEMENTAL_RECORD_UI":"C004450"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":3,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"S01AA25","allCodes":["S01AA25"]},"biosimilarFilings":[],"recentPublications":[{"date":"2023 Jan 17","pmid":"36353978","title":"Bacterial Dehydrogenases Facilitate Oxidative Inactivation and Bioremediation of Chloramphenicol.","journal":"Chembiochem : a European journal of chemical biology"},{"date":"1989 May-Jun","pmid":"2745365","title":"Derivative spectrophotometric determination of clotrimazole in single formulations and in combination with other drugs.","journal":"Journal - Association of Official Analytical Chemists"},{"date":"1987 Mar-Apr","pmid":"2954808","title":"[Contact allergy to clotrimazole and azidamfenicol].","journal":"Dermatosen in Beruf und Umwelt. Occupation and environment"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Azidamfenicol is a small molecule antibiotic. It is also known by several other names, including Posifenicol, Azidanfenicol, Azidoamfenicol, and Azidamfenicol.","enrichmentLevel":5,"visitCount":0,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:49:57.897178+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}